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Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors During the COVID-19 Epidemic in Denmark
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2021-11-09 , DOI: 10.1093/infdis/jiab566
Kathrine Agergård Kaspersen 1, 2 , Lotte Hindhede 1 , Jens Kjærgaard Boldsen 1, 2 , Susan Mikkelsen 1 , Lasse Skafte Vestergaard 3 , Ann-Sofie Nicole Berthelsen 3 , Ida Rask Moustsen-Helms 3 , Dorte Kinggaard Holm 4 , Anna Christine Nilsson 4 , Susanne Gjørup Sækmose 5 , Erik Sørensen 6 , Lene Holm Harritshøj 6 , Bitten Aagaard 7 , Henrik Hjalgrim 8 , Søren Thue Lillevang 4 , Charlotte Sværke Jørgensen 9 , Tyra Grove Krause 3 , Henrik Ullum 10 , Ole Birger Vestager Pedersen 5, 11 , Sisse Rye Ostrowski 6, 11 , Christian Erikstrup 1, 12
Affiliation  

Background Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods Danish blood donors aged 17–69 years donating blood October 2020–February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17–69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61–69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions In this nationwide study, the IFR was very low among people <51 years without comorbidity.

中文翻译:

在丹麦 COVID-19 流行期间使用献血者的抗体筛查按年龄和合并症状态估计 SARS-CoV-2 感染死亡率

背景研究表明健康个体的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染死亡率 (IFR) 是必要的。我们使用来自丹麦献血者的大型血清调查数据和全国范围内有关 2019 年冠状病毒病 (COVID-19) 死亡率的数据,按年龄和合并症状态估计 IFR。方法 对 2020 年 10 月至 2021 年 2 月献血的 17-69 岁丹麦献血者进行了商业化 SARS-CoV-2 总抗体检测。IFR 估计为 2020 年第 11 至 42 周和 2020 年第 43 周至 2021 年第 6 周,代表丹麦 COVID-19 流行的前 2 波。结果 总共对 84944 名献血者进行了抗体检测。2020 年 10 月的血清阳性率为 2%,2021 年 2 月为 7%。在 3898039 名 17-69 岁的丹麦居民中,有 249 人死亡。在 2 波期间没有合并症的 <51 岁人群的 IFR 较低(综合 IFR=3.36/100000 感染)。没有合并症的 61-69 岁人群的 IFR 低于 3‰。IFR 随着年龄和合并症的增加而增加,但从第一波到第二波下降。结论 在这项全国性研究中,没有合并症的<51 岁人群的 IFR 非常低。
更新日期:2021-11-09
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