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Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians
CA: A Cancer Journal for Clinicians ( IF 254.7 ) Pub Date : 2021-11-18 , DOI: 10.3322/caac.21707
William A Hall 1 , Eric Paulson 1 , X Allen Li 1 , Beth Erickson 1 , Christopher Schultz 1 , Alison Tree 2 , Musaddiq Awan 1 , Daniel A Low 3 , Brigid A McDonald 4 , Travis Salzillo 4 , Carri K Glide-Hurst 5 , Amar U Kishan 3 , Clifton D Fuller 4
Affiliation  

Radiation therapy (RT) continues to play an important role in the treatment of cancer. Adaptive RT (ART) is a novel method through which RT treatments are evolving. With the ART approach, computed tomography or magnetic resonance (MR) images are obtained as part of the treatment delivery process. This enables the adaptation of the irradiated volume to account for changes in organ and/or tumor position, movement, size, or shape that may occur over the course of treatment. The advantages and challenges of ART maybe somewhat abstract to oncologists and clinicians outside of the specialty of radiation oncology. ART is positioned to affect many different types of cancer. There is a wide spectrum of hypothesized benefits, from small toxicity improvements to meaningful gains in overall survival. The use and application of this novel technology should be understood by the oncologic community at large, such that it can be appropriately contextualized within the landscape of cancer therapies. Likewise, the need to test these advances is pressing. MR-guided ART (MRgART) is an emerging, extended modality of ART that expands upon and further advances the capabilities of ART. MRgART presents unique opportunities to iteratively improve adaptive image guidance. However, although the MRgART adaptive process advances ART to previously unattained levels, it can be more expensive, time-consuming, and complex. In this review, the authors present an overview for clinicians describing the process of ART and specifically MRgART.

中文翻译:

磁共振直线加速器技术和自适应放射治疗:临床医生概述

放射治疗 (RT) 在癌症治疗中继续发挥重要作用。适应性放疗 (ART) 是一种新的放疗治疗方法。借助 ART 方法,可以获得计算机断层扫描或磁共振 (MR) 图像作为治疗实施过程的一部分。这使得照射体积能够适应在治疗过程中可能发生的器官和/或肿瘤位置、运动、大小或形状的变化。ART 的优势和挑战对于放射肿瘤学专业之外的肿瘤学家和临床医生来说可能有些抽象。ART 的定位是影响许多不同类型的癌症。有广泛的假设益处,从小的毒性改善到总体生存期的有意义的增益。这种新技术的使用和应用应该被整个肿瘤学界所理解,这样它就可以在癌症治疗的领域中得到适当的背景化。同样,测试这些进步的需求也很紧迫。MR 引导的 ART (MRgART) 是一种新兴的、扩展的 ART 模式,它扩展并进一步提高了 ART 的能力。MRgART 为迭代改进自适应图像引导提供了独特的机会。然而,尽管 MRgART 自适应过程将 ART 提升到了以前无法达到的水平,但它可能更加昂贵、耗时且复杂。在这篇综述中,作者为临床医生提供了一个概述,描述了 ART 的过程,特别是 MRgART。这样它就可以在癌症治疗的范围内适当地结合起来。同样,测试这些进步的需求也很紧迫。MR 引导的 ART (MRgART) 是一种新兴的、扩展的 ART 模式,它扩展并进一步提高了 ART 的能力。MRgART 为迭代改进自适应图像引导提供了独特的机会。然而,尽管 MRgART 自适应过程将 ART 提升到了以前无法达到的水平,但它可能更加昂贵、耗时且复杂。在这篇综述中,作者为临床医生提供了一个概述,描述了 ART 的过程,特别是 MRgART。这样它就可以在癌症治疗的范围内适当地结合起来。同样,测试这些进步的需求也很紧迫。MR 引导的 ART (MRgART) 是一种新兴的、扩展的 ART 模式,它扩展并进一步提高了 ART 的能力。MRgART 为迭代改进自适应图像引导提供了独特的机会。然而,尽管 MRgART 自适应过程将 ART 提升到了以前无法达到的水平,但它可能更加昂贵、耗时且复杂。在这篇综述中,作者为临床医生提供了一个概述,描述了 ART 的过程,特别是 MRgART。MRgART 为迭代改进自适应图像引导提供了独特的机会。然而,尽管 MRgART 自适应过程将 ART 提升到了以前无法达到的水平,但它可能更加昂贵、耗时且复杂。在这篇综述中,作者为临床医生提供了一个概述,描述了 ART 的过程,特别是 MRgART。MRgART 为迭代改进自适应图像引导提供了独特的机会。然而,尽管 MRgART 自适应过程将 ART 提升到了以前无法达到的水平,但它可能更加昂贵、耗时且复杂。在这篇综述中,作者为临床医生提供了一个概述,描述了 ART 的过程,特别是 MRgART。
更新日期:2021-11-18
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