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Independent infections of porcine deltacoronavirus among Haitian children
Nature ( IF 64.8 ) Pub Date : 2021-11-17 , DOI: 10.1038/s41586-021-04111-z
John A Lednicky 1, 2 , Massimiliano S Tagliamonte 1, 3 , Sarah K White 1, 2 , Maha A Elbadry 1, 2 , Md Mahbubul Alam 1, 2 , Caroline J Stephenson 1, 2 , Tania S Bonny 1, 2 , Julia C Loeb 1, 2 , Taina Telisma 4 , Sonese Chavannes 4 , David A Ostrov 1, 3 , Carla Mavian 1, 3 , Valery Madsen Beau De Rochars 1, 5 , Marco Salemi 1, 3 , J Glenn Morris 1, 6
Affiliation  

Coronaviruses have caused three major epidemics since 2003, including the ongoing SARS-CoV-2 pandemic. In each case, the emergence of coronavirus in our species has been associated with zoonotic transmissions from animal reservoirs1,2, underscoring how prone such pathogens are to spill over and adapt to new species. Among the four recognized genera of the family Coronaviridae, human infections reported so far have been limited to alphacoronaviruses and betacoronaviruses3,4,5. Here we identify porcine deltacoronavirus strains in plasma samples of three Haitian children with acute undifferentiated febrile illness. Genomic and evolutionary analyses reveal that human infections were the result of at least two independent zoonoses of distinct viral lineages that acquired the same mutational signature in the genes encoding Nsp15 and the spike glycoprotein. In particular, structural analysis predicts that one of the changes in the spike S1 subunit, which contains the receptor-binding domain, may affect the flexibility of the protein and its binding to the host cell receptor. Our findings highlight the potential for evolutionary change and adaptation leading to human infections by coronaviruses outside of the previously recognized human-associated coronavirus groups, particularly in settings where there may be close human–animal contact.



中文翻译:

海地儿童独立感染猪δ冠状病毒

自 2003 年以来,冠状病毒已引起三大流行病,包括持续的 SARS-CoV-2 大流行。在每种情况下,冠状病毒在我们物种中的出现都与动物宿主1,2 的人畜共患病传播有关,这突显了此类病原体扩散和适应新物种的可能性。在冠状病毒科的四个公认属中,迄今为止报告的人类感染仅限于甲型冠状病毒和乙型冠状病毒3,4,5. 在这里,我们在三名患有急性未分化发热性疾病的海地儿童的血浆样本中鉴定了猪 deltacoronavirus 菌株。基因组和进化分析表明,人类感染是至少两种不同病毒谱系的独立人畜共患病的结果,这些病毒谱系在编码 Nsp15 和刺突糖蛋白的基因中获得了相同的突变特征。特别是,结构分析预测,包含受体结合域的刺突 S1 亚基的变化之一可能会影响蛋白质的灵活性及其与宿主细胞受体的结合。我们的研究结果强调了进化变化和适应的可能性,导致人类感染先前公认的人类相关冠状病毒组之外的冠状病毒,

更新日期:2021-11-17
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