Key studies published in 2021 demonstrated mechanisms that drive macrophage–fibroblast pathogenicity in Crohn’s disease, developed multi-omics profiles to predict response to biological therapy, and suggested potential complementary treatments and new therapeutic agents in inflammatory bowel disease (IBD) therapy. These results represent important progress towards precision medicine for patients with IBD.

中文翻译：

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IBD 中的精准医学：基因、药物、缺陷和组学

2021 年发表的关键研究证明了驱动克罗恩病中巨噬细胞-成纤维细胞致病性的机制，开发了多组学谱来预测对生物治疗的反应，并提出了炎症性肠病 (IBD) 治疗中的潜在补充治疗和新治疗剂。这些结果代表了 IBD 患者在精准医疗方面的重要进展。