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Promotech: a general tool for bacterial promoter recognition
Genome Biology ( IF 12.3 ) Pub Date : 2021-11-17 , DOI: 10.1186/s13059-021-02514-9
Ruben Chevez-Guardado 1 , Lourdes Peña-Castillo 1, 2
Affiliation  

Promoters are genomic regions where the transcription machinery binds to initiate the transcription of specific genes. Computational tools for identifying bacterial promoters have been around for decades. However, most of these tools were designed to recognize promoters in one or few bacterial species. Here, we present Promotech, a machine-learning-based method for promoter recognition in a wide range of bacterial species. We compare Promotech’s performance with the performance of five other promoter prediction methods. Promotech outperforms these other programs in terms of area under the precision-recall curve (AUPRC) or precision at the same level of recall. Promotech is available at https://github.com/BioinformaticsLabAtMUN/PromoTech .

中文翻译:

Promotech:细菌启动子识别的通用工具

启动子是转录机制结合以启动特定基因转录的基因组区域。用于识别细菌启动子的计算工具已经存在了几十年。然而,这些工具中的大多数旨在识别一种或几种细菌物种中的启动子。在这里,我们介绍了 Promooch,这是一种基于机器学习的方法,用于在广泛的细菌物种中识别启动子。我们将Promooch 的性能与其他五种启动子预测方法的性能进行比较。在精确召回曲线 (AUPRC) 下的面积或相同召回水平的精确度方面,Promotech 优于这些其他程序。Promotionch 可在 https://github.com/BioinformaticsLabAtMUN/PromoTech 获得。
更新日期:2021-11-17
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