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Electrochemical synthesis of functionalized gem-difluoroalkenes with diverse alkyl sources via a defluorinative alkylation process
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2021-11-03 , DOI: 10.1039/d1qo01460a
Haoxiang Zhang 1 , Mengze Liang 1 , Xiao Zhang 1 , Meng-Ke He 2 , Chao Yang 1 , Lin Guo 1 , Wujiong Xia 1, 3
Affiliation  

An electrochemical defluorinative alkylation protocol of α-trifluoromethyl alkenes is described. This reaction enables the preparation of functionalized gem-difluoroalkenes with the use of diverse alkyl sources including organohalides, N-hydroxyphthalimide (NHP) esters and Katritzky salts. This method exhibits lots of synthetic advantages including mild conditions, simple operation, and convenience of amplification, and provides a new route for the synthesis of gem-difluoroalkenes.

中文翻译:

通过脱氟烷基化过程电化学合成具有多种烷基来源的功能化的偕二氟烯烃

描述了 α-三氟甲基烯烃的电化学脱氟烷基化方案。该反应能够使用包括有机卤化物、N-羟基邻苯二甲酰亚胺(NHP) 酯和卡特里茨基盐在内的多种烷基来源制备功能化的二氟烯烃。该方法具有条件温和、操作简单、扩增方便等诸多合成优点,为二氟烯烃的合成提供了一条新途径。
更新日期:2021-12-01
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