The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment. Thus, targeted multimodal therapeutic approaches need to be strategically developed to successfully control tumor growth and prevent metastatic burden. Inflammation has long been recognized as a hallmark of cancer and plays a key role in the tumorigenesis and progression of the disease. Several epidemiological, clinical, and preclinical studies have shown that traditional nonsteroidal anti-inflammatory drugs (NSAIDs) exhibit anticancer activities. This Perspective reports the most recent outcomes for the treatment and prevention of different types of cancers for several NSAIDs alone or in combination with current chemotherapeutic drugs. Furthermore, an extensive review of the most promising structural modifications is reported, such as phospho, H₂S, and NO releasing-, selenium-, metal complex-, and natural product-NSAIDs, among others. We also provide a perspective about the new strategies used to obtain more efficient NSAID- or NSAID derivative- formulations for targeted delivery.

中文翻译：

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非甾体抗炎药：癌症治疗和预防管道中的老熟人─结构调节、作用机制和光明未来

目前化疗药物的局限性仍然是癌症治疗的主要问题。因此，需要战略性地开发有针对性的多模式治疗方法，以成功控制肿瘤生长并防止转移负担。长期以来，炎症一直被认为是癌症的标志，并且在该疾病的肿瘤发生和进展中起关键作用。多项流行病学、临床和临床前研究表明，传统的非甾体抗炎药 (NSAID) 具有抗癌活性。该观点报告了几种非甾体抗炎药单独或与当前化疗药物联合治疗和预防不同类型癌症的最新结果。此外，报告了对最有希望的结构修饰的广泛审查，例如磷酸化、H₂ S 和 NO 释放、硒、金属络合物和天然产物 NSAID 等。我们还提供了有关用于获得更有效的 NSAID 或 NSAID 衍生物制剂以进行靶向递送的新策略的观点。