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Fins of Fury or Fainéant: Fluoxetine impacts the aggressive behavior of fighting fish (Betta splendens)
Behavioural Processes ( IF 1.3 ) Pub Date : 2021-11-17 , DOI: 10.1016/j.beproc.2021.104544
Susan M Greene 1 , Allen D Szalda-Petree 2
Affiliation  

While an extensive literature has demonstrated that the selective serotonin reuptake inhibitor (SSRI) antidepressant fluoxetine, disrupts aggressive behavior in male Betta splendens the behavioral mechanisms underlying this disruption remain unknown. To elucidate the behavioral mechanism underlying fluoxetine, male fish were acutely exposed to a 10 μmol (0.0034578 μg/L) concentration of fluoxetine for 25 days using an ABA design. Male Betta splendens are naturally aggressive fish with well-studied and patterned behavioral responses. Importantly, aggressive behavior in this species can be conditionally primed allowing for examination of motivational components of behavior in addition to motor performance. The present study focused on using female fish as an ecologically relevant prime for eliciting aggressive behavior as a means of examining the motivational and motoric effects of fluoxetine. We found that male courtship with a female was strongly correlated with aggressive responding against a mirror. However, despite the strong correlation male fish were not found to have different levels of aggression or changes in aggressive responding when compared to males not primed with a female. Also, latency was not different between the no female prime and female prime males for either the excitatory mirror condition or inhibitory white wall condition, of which the fish had no preference. However, fluoxetine was found to have profound effects on all males in the study regardless of prime type, with increases in latency for the mirror and white wall and decreases in aggressive responding to the mirror. These results support the hypothesis that fluoxetine impairs aggressive motivation and movement in Betta splendens.



中文翻译:

Fins of Fury 或 Fainéant:氟西汀会影响斗鱼(Betta splendens)的攻击行为

虽然大量文献表明选择性血清素再摄取抑制剂 (SSRI) 抗抑郁药氟西汀会破坏雄性斗鱼的攻击行为,但这种破坏背后的行为机制仍然未知。为了阐明氟西汀的行为机制,使用 ABA 设计将雄鱼急性暴露于 10 μmol (0.0034578 μg/L) 浓度的氟西汀 25 天。雄性斗鱼灿烂是天生具有攻击性的鱼,具有经过充分研究和模式化的行为反应。重要的是,该物种的攻击行为可以有条件地引发,从而可以检查除运动表现之外的行为动机成分。本研究的重点是使用雌性鱼作为引发攻击行为的生态相关素数,作为检查氟西汀的动机和运动效果的一种手段。我们发现男性对女性的求爱与对镜子的攻击性反应密切相关。然而,尽管存在很强的相关性,但与未与雌性接触的雄性鱼相比,雄性鱼并未发现具有不同程度的攻击性或攻击性反应的变化。还,对于兴奋性镜像条件或抑制性白壁条件,无雌性原始和雌性原始雄性之间的潜伏期没有差异,鱼没有偏好。然而,发现氟西汀对研究中的所有男性都有深远的影响,无论其主要类型如何,镜子和白墙的潜伏期增加,对镜子的积极反应减少。这些结果支持氟西汀损害攻击动机和运动的假设斗鱼灿烂

更新日期:2021-11-28
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