Background: Optical Coherence Tomography Angiography (OCTA) is a valuable imaging tool for the diagnosis of several retinal and choroidal diseases. Its role in ocular oncology is clinically promising but still controversial. In this review we report the main applications and limits of the use of OCTA for the study of intraocular tumors. Summary: OCTA allows a rapid, safe, low-cost and high-resolution visualization of the retinal and choroidal vasculature. Attempts have been made to use this technology in ocular oncology to differentiate benign and malignant lesions and to assist physicians in the evaluation and monitoring of post-treatment complications. Main limitations include failure in correct segmentation due to tumor inner profile or thickness, poor penetration of laser into the lesion, masking effect from overlying fluid and media opacities and poor fixation. Key messages: The main applications of OCTA in ocular oncology consist in the documentation of tumor-associated choroidal neovascularizations and the study of vascular changes following tumor treatments. In particular, the diffusion of wide-field protocols makes OCTA suitable for the diagnosis and follow-up of radiation chorio-retinopathy allowing a detailed visualoization of both macular and peripheral ischemic changes. Optimistically, future innovations in OCTA technology may offer new perspectives in the diagnosis and follow-up of intraocular tumors.


中文翻译：

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OCTA 在眼肿瘤学中的临床应用：珍珠和陷阱

背景：光学相干断层扫描血管造影 (OCTA) 是一种有价值的成像工具，可用于诊断多种视网膜和脉络膜疾病。它在眼肿瘤学中的作用在临床上很有希望，但仍存在争议。在这篇综述中，我们报告了使用 OCTA 研究眼内肿瘤的主要应用和局限性。总结：OCTA 允许快速、安全、低成本和高分辨率地可视化视网膜和脉络膜脉管系统。已经尝试在眼肿瘤学中使用该技术来区分良性和恶性病变，并协助医生评估和监测治疗后并发症。主要局限性包括由于肿瘤内部轮廓或厚度导致无法正确分割，激光对病灶的穿透力差，覆盖液体和介质混浊以及固定不良造成的掩蔽效应。关键信息：OCTA 在眼肿瘤学中的主要应用包括肿瘤相关脉络膜新生血管的记录和肿瘤治疗后血管变化的研究。特别是，广域协议的传播使 OCTA 适用于放射性绒毛膜视网膜病变的诊断和随访，允许对黄斑和周围缺血性变化进行详细的可视化。乐观地说，未来 OCTA 技术的创新可能会为眼内肿瘤的诊断和随访提供新的视角。特别是，广域协议的传播使 OCTA 适用于放射性绒毛膜视网膜病变的诊断和随访，允许对黄斑和周围缺血性变化进行详细的可视化。乐观地说，未来 OCTA 技术的创新可能会为眼内肿瘤的诊断和随访提供新的视角。特别是，广域协议的传播使 OCTA 适用于放射性绒毛膜视网膜病变的诊断和随访，允许对黄斑和周围缺血性变化进行详细的可视化。乐观地说，未来 OCTA 技术的创新可能会为眼内肿瘤的诊断和随访提供新的视角。