Sensitive identification of neoantigens and cognate TCRs in human solid tumors,Nature Biotechnology

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Sensitive identification of neoantigens and cognate TCRs in human solid tumors
Nature Biotechnology ( IF 46.9 ) Pub Date : 2021-11-15 , DOI: 10.1038/s41587-021-01072-6
Marion Arnaud _{1,

2,

3} , Johanna Chiffelle _{1,

2,

3} , Raphael Genolet _{1,

2,

3} , Blanca Navarro Rodrigo _{1,

2,

3} , Marta A S Perez _{1,

4} , Florian Huber _{1,

2,

3} , Morgane Magnin _{1,

2,

3} , Tu Nguyen-Ngoc _{1,

3} , Philippe Guillaume _{1,

2,

3} , Petra Baumgaertner _{1,

2,

3} , Chloe Chong _{1,

2,

3} , Brian J Stevenson _{1,

4} , David Gfeller _{1,

3,

4} , Melita Irving _{1,

3} , Daniel E Speiser _{1,

3} , Julien Schmidt _{1,

2,

3} , Vincent Zoete _{1,

3,

4} , Lana E Kandalaft _{1,

2,

3} , Michal Bassani-Sternberg _{1,

2,

3} , Sara Bobisse _{1,

2,

3} , George Coukos _{1,

2,

3} , Alexandre Harari _{1,

2,

3}

Affiliation

The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.

中文翻译：

人实体瘤中新抗原和同源 TCR 的灵敏鉴定

由于对每种肿瘤抗原具有特异性的 T 细胞频率较低，因此患者特异性肿瘤抗原的鉴定变得复杂。在这里，我们描述了 NeoScreen，这是一种能够敏感识别稀有肿瘤 (neo) 抗原和肿瘤浸润淋巴细胞表达的同源 T 细胞受体 (TCR) 的方法。用 NeoScreen 鉴定的肿瘤抗原特异性 TCR 转导的 T 细胞介导患者来源的异种移植小鼠中已建立肿瘤的消退。

更新日期：2021-11-15

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