State and local health departments established the California Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Respiratory Virus Sentinel Surveillance System to conduct enhanced surveillance for SARS-CoV-2 and other respiratory pathogens at sentinel outpatient testing sites in 10 counties throughout California, USA. We describe results obtained during May 10, 2020‒June 12, 2021, and compare persons with positive and negative SARS-CoV-2 PCR results by using Poisson regression. We detected SARS-CoV-2 in 1,696 (19.6%) of 8,662 specimens. Among 7,851 specimens tested by respiratory panel, rhinovirus/enterovirus was detected in 906 (11.5%) specimens and other respiratory pathogens in 136 (1.7%) specimens. We also detected 23 co-infections with SARS-CoV-2 and another pathogen. SARS-CoV-2 positivity was associated with male participants, an age of 35–49 years, Latino race/ethnicity, obesity, and work in transportation occupations. Sentinel surveillance can provide useful virologic and epidemiologic data to supplement other disease monitoring activities and might become increasingly useful as routine testing decreases.

州和地方卫生部门建立了加州严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 和呼吸道病毒哨点监测系统，在全国 10 个县的哨点门诊检测点加强对 SARS-CoV-2 和其他呼吸道病原体的监测美国加利福尼亚州。我们描述了2020年5月10日至2021年6月12日期间获得的结果，并使用泊松回归比较了SARS-CoV-2 PCR结果呈阳性和阴性的人。我们在 8,662 份样本中的 1,696 份（19.6%）中检测到 SARS-CoV-2。在呼吸道专家组检测的7,851份样本中，906份（11.5%）样本检出鼻病毒/肠道病毒，136份（1.7%）样本检出其他呼吸道病原体。我们还检测到 23 例 SARS-CoV-2 和另一种病原体的混合感染。SARS-CoV-2 阳性与男性参与者、年龄 35-49 岁、拉丁裔种族/民族、肥胖和从事交通运输职业相关。哨点监测可以提供有用的病毒学和流行病学数据来补充其他疾病监测活动，并且随着常规检测的减少可能变得越来越有用。