There are very few published cases of total anterior staphyloma, all of which have been reported as secondary to fungal keratitis. This study reports the clinical and histopathological findings and subsequent management of a 27-year-old healthy female patient who developed total anterior staphyloma after poor compliance with treatment for clinically diagnosed acanthamoeba keratitis. She underwent a successful evisceration with good long-term results. This case highlights that total anterior staphyloma may also result from untreated keratitis which is not fungal in origin. In cases of fungal and acanthamoeba keratitis, patient compliance with both treatment and follow-up is paramount to avoid vision-threatening sequelae that present significant challenges in their management.

很少有已发表的全前部葡萄肿病例，所有这些病例均被报道为继发于真菌性角膜炎。本研究报告了一名 27 岁健康女性患者的临床和组织病理学发现以及随后的管理，该患者在临床诊断的棘阿米巴角膜炎治疗依从性差后发展为完全前葡萄肿。她进行了一次成功的掏膛手术，取得了良好的长期效果。该病例强调，前部葡萄肿也可能由未经治疗的非真菌性角膜炎引起。在真菌性角膜炎和棘阿米巴角膜炎的病例中，患者对治疗和随访的依从性对于避免威胁视力的后遗症至关重要，这些后遗症对其管理提出了重大挑战。