PURPOSE

To determine whether persistent hypertransmission defects (hyperTDs), previously shown to have a greatest linear dimension (GLD) ≥250 µm on en face swept source OCT (SS-OCT) images, serve as a stand-alone early biomarker for the future formation geographic atrophy (GA).

DESIGN

Post hoc cohort study using a subgroup of a prospective study.

METHODS

Patients with intermediate age-related macular degeneration (iAMD) underwent 6- × 6-mm SS-OCT raster scans at baseline and during their follow-up period. En face images were generated using a slab with segmentation boundaries positioned 64 µm to 400 µm beneath the Bruch's membrane. Two graders independently evaluated all en face structural images for the presence of hyperTDs with a GLD ≥250 µm and GA.

RESULTS

A total of 190 eyes were included with a mean ± SD follow-up of 31 ± 13.2 months. At baseline, 31 eyes (16%) had at least 1 hyperTD ≥250 µm, and 13 eyes (42%) progressed to GA. In those eyes without a hyperTD ≥250 µm at baseline, 42 (26%) developed hyperTDs ≥250 µm during their follow-up, and 11 eyes (7%) progressed to GA. At the last available follow-up visit, 25 eyes (13%) progressed to GA and of these 25 eyes, a prior hyperTD ≥250 µm was detected in 24 eyes before GA formed. A time-dependent Cox-survival regression analysis estimated an 80-fold (95% CI, 10.7-614, P < .001) increased risk of developing GA once a hyperTD ≥250 µm appeared.

CONCLUSIONS

Persistent hyperTDs detected on en face OCT images were shown to serve as an early stand-alone OCT biomarker for the future formation of GA.

中文翻译：

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在 En Face Swept Source 光学计算机断层扫描图像上检测到的持续性超透射缺陷预测年龄相关性黄斑变性中地理萎缩的形成

目的

确定是否持续超传输缺陷 (hyperTDs)，以前显示有一个最大的线性尺寸 (GLD) ≥ 250 µm 在en 面部扫描源 OCT (SS-OCT) 图像，作为未来地层地理的独立早期生物标志物萎缩（GA）。

设计

使用前瞻性研究的一个子组进行事后队列研究。

方法

中期年龄相关性黄斑变性 (iAMD) 患者在基线和随访期间接受了 6-×6-mm SS-OCT 光栅扫描。En 面部图像是使用一块板生成的，其分割边界位于 Bruch 膜下方 64 µm 至 400 µm 处。两名评分者独立评估所有正面结构图像是否存在 GLD ≥ 250 µm 和 GA 的 hyperTD。

结果

总共包括 190 只眼，平均随访 31 ± 13.2 个月。在基线时，31 只眼 (16%) 至少有 1 个 hyperTD ≥250 µm，13 只眼 (42%) 进展为 GA。在那些基线时没有 hyperTD ≥ 250 µm 的眼中，42 只眼 (26%) 在随访期间出现了 hyperTD ≥ 250 µm，11 只眼 (7%) 进展为 GA。在最后一次随访时，25 只眼 (13%) 进展为 GA，在这 25 只眼中，有 24 只眼在 GA 形成前检测到先前的 hyperTD ≥250 µm。时间依赖性 Cox 生存回归分析估计，一旦 hyperTD ≥ 250 µm 出现，患 GA 的风险就会增加80 倍（95% CI，10.7-614，P < .001）。

结论

在en face OCT 图像上检测到的持久性 hyperTDs被证明可以作为未来 GA 形成的早期独立 OCT 生物标志物。