Impact of COVID-19 infection on short-term outcome in patients referred to stress myocardial perfusion imaging,European Journal of Nuclear Medicine and Molecular Imaging

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Impact of COVID-19 infection on short-term outcome in patients referred to stress myocardial perfusion imaging
European Journal of Nuclear Medicine and Molecular Imaging ( IF 9.1 ) Pub Date : 2021-11-13 , DOI: 10.1007/s00259-021-05619-2
Roberta Assante ₁ , Adriana D'Antonio ₁ , Teresa Mannarino ₁ , Valeria Gaudieri ₁ , Emilia Zampella ₁ , Ciro Gabriele Mainolfi ₁ , Valeria Cantoni ₁ , Roberta Green ₁ , Elisa Caiazzo ₁ , Carmela Nappi ₁ , Emanuele Criscuolo ₁ , Roberto Bologna ₁ , Giulia Zumbo ₁ , Mario Petretta ₂ , Alberto Cuocolo ₁ , Wanda Acampa ₁

Affiliation

Purpose

We assessed the impact of COVID-19 infection on cardiovascular events in patients with suspected or known coronary artery disease (CAD) referred to stress single-photon emission computed tomography myocardial perfusion imaging (MPS).

Methods

A total of 960 consecutive patients with suspected or known CAD were submitted by referring physicians to stress MPS for assessment of myocardial ischemia between January 2018 and June 2019. All patients underwent stress-optional rest MPS. Perfusion defects were quantitated as % of LV myocardium and expressed as total perfusion defect (TPD), representing the defect extent and severity. A TPD ≥ 5% was considered abnormal.

Results

During a mean follow-up of 27 months (range 4–38) 31 events occurred. Moreover, 55 (6%) patients had a COVID-19 infection. The median time from index MPS to COVID-19 infection was 16 months (range 6–24). At Cox multivariable analysis, abnormal MPS and COVID-19 infection resulted as independent predictors of events. There were no significant differences in annualized event rate in COVID-19 patients with or without abnormal MPS (p = 0.56). Differently, in patients without COVID-19, the presence of abnormal MPS was associated with higher event rate (p < .001). Patients with infection compared to those without had a higher event rate in the presence of both normal and abnormal TPD.

Conclusion

In patients with suspected or known CAD, the presence of COVID-19 infection during a short-term follow-up was associated with a higher rate of cardiovascular events.

中文翻译：

COVID-19感染对应激心肌灌注成像患者短期预后的影响

目的

我们评估了 COVID-19 感染对疑似或已知冠状动脉疾病 (CAD) 患者心血管事件的影响，称为应力单光子发射计算机断层扫描心肌灌注成像 (MPS)。

方法

在 2018 年 1 月至 2019 年 6 月期间，转诊医生将总共 960 名疑似或已知 CAD 的连续患者提交给压力 MPS 以评估心肌缺血。所有患者都接受了压力可选的休息 MPS。灌注缺损被量化为 LV 心肌的百分比，并表示为总灌注缺损 (TPD)，代表缺损程度和严重程度。TPD ≥ 5% 被认为是异常的。

结果

在 27 个月（范围 4-38）的平均随访期间，发生了 31 起事件。此外，55 名 (6%) 患者感染了 COVID-19。从指数 MPS 到 COVID-19 感染的中位时间为 16 个月（范围 6-24）。在 Cox 多变量分析中，异常 MPS 和 COVID-19 感染是事件的独立预测因素。有或没有 MPS 异常的 COVID-19 患者的年化事件发生率没有显着差异（p = 0.56）。不同的是，在没有 COVID-19 的患者中，异常 MPS 的存在与较高的事件发生率相关 ( p < .001)。与没有感染的患者相比，在存在正常和异常 TPD 的情况下，感染患者的事件发生率更高。