Spherical agglomeration technology can produce high-performance spherical particles in a single crystallization unit, although it is still challenging to control the particle size and shape. To solve this issue, a two-step bridging (TSB) mechanism containing a preconditioning period, size period, and shape period is proposed. The dynamic balance among the forces of adhesion, dispersion, and capillary action in the multi-liquid phases plays a key role. This is fully considered to establish the TSB-based thermodynamic size model and particle design framework by weighting the force action regions in multi-liquid phases with dynamic composition. The spherical agglomerates of benzoic acid, celecoxib, and salicylic acid with narrow particle size distributions and tunable particle size ranges of 2000–5000, 800–3500, and 1500–4500 μm, respectively, were designed and prepared successfully, showing good correlation with the calculation, which is superior to the reported methods and indicates that the mechanism has certain universality and guiding significance.

中文翻译：

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通过开发两步桥接机制和模型设计结晶过程中的球形团聚体尺寸

球形附聚技术可以在单个结晶单元中生产高性能的球形颗粒，尽管控制颗粒尺寸和形状仍然具有挑战性。为了解决这个问题，提出了一种包含预处理周期、尺寸周期和形状周期的两步桥接（TSB）机制。多液相中的粘附力、分散力和毛细作用力之间的动态平衡起着关键作用。这充分考虑了建立基于TSB的热力学尺寸模型和粒子设计框架，通过对具有动态成分的多液相中的力作用区域进行加权。苯甲酸、塞来昔布和水杨酸的球形团聚体具有窄的粒径分布和可调的粒径范围，分别为 2000-5000、800-3500 和 1500-4500 μm，