Body temperature decrease, in mice administered with a drug that selectively inhibits F₁F₀ ATP hydrolysis (which doesn’t inhibit F₁F₀ ATP synthesis), is evidence that F₁F₀ ATP hydrolysis is used for metabolic heat generation in vivo. It being pivotal to homeothermy, which is a new discovery. This drug, capable of dose-dependently lowering body temperature, might slow aging and extend lifespan (combating all age-related diseases thereby). Because slightly lower body temperature corresponds with a much longer lifespan in mice and humans. Alzheimer’s, a disease of aging, can cause a higher body temperature (that accelerates its progression), which this drug might counteract. Across twelve investigated species, less F₁F₀ ATP hydrolysis correlates with greater maximal lifespan. A case for causality is made. Selective drug inhibition of F₁F₀ ATP hydrolysis exerts potent anti-cancer activity in vitro. Teaching F₁F₀ ATP hydrolysis as a new cancer drug target.

中文翻译：

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F1F0 ATP 水解是代谢率的决定因素，与寿命相关，是癌症的弱点

_{在使用选择性抑制 F 1} F ₀ ATP 水解（不抑制 F ₁ F ₀ ATP 合成）的药物给药的小鼠中，体温下降是 F ₁ F ₀ ATP 水解用于体内代谢热产生的证据. 它对恒温至关重要，这是一个新发现。这种药物能够以剂量依赖性方式降低体温，可能会减缓衰老并延长寿命（从而对抗所有与年龄相关的疾病）。因为稍低的体温对应于老鼠和人类更长的寿命。阿尔茨海默氏症是一种衰老疾病，可导致体温升高（加速其进展），这种药物可能会抵消这种情况。在 12 个研究物种中，较少的 F ₁ F ₀ ATP 水解与较长的最大寿命相关。提出了因果关系的案例。_{F 1} F ₀ ATP 水解的选择性药物抑制在体外发挥有效的抗癌活性。教学 F ₁ F₀ ATP水解作为新的抗癌药物靶点。