PURPOSE Upon the outbreak of 2019, novel coronavirus (COVID-19) pandemic confirmed the cases surpassed 20 million. Despite a few reports identified the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with ocular manifestations, it may assess the ocular symptoms of patients with the COVID-19 by ophthalmologists facilitate the diagnosis and prevent transmission. METHODS A total of 60 patients with the COVID-19 admitted to Baghiatallah hospital from March 2020 to May 2020 were retrospectively reviewed and analyzed for the ocular manifestations, blood tests, and reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV-2 using nasopharyngeal and conjunctival swabs. RESULTS Among 60 included patients with clinically confirmed COVID-19, the median age 58.36 years (IQR: 30-88 years), 27 (45%) were male. Furthermore, 29 (48%) and 5 (8%) patients yielded positive for SARS-CoV-2 on RT-PCR from nasopharyngeal swabs and conjunctival specimens, respectively. Among 60 patients, 10 (16%) and 3 (5%), respectively, had the ocular manifestations and positive results for SARS-CoV-2 on RT-PCR from conjunctival and nasopharyngeal swabs. CONCLUSION Although the positive rate of tear RT-PCR rate is not noticeable as nasopharyngeal swabs yet, COVID-19 transmission through the eyes is biologically plausible.

中文翻译：

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在 ICU 入院的 SARS-CoV-2 感染患者泪液中检测 COVID-19。

目的 2019 年爆发后，新型冠状病毒 (COVID-19) 大流行确认病例超过 2000 万。尽管有一些报告确定了严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 与眼部表现的关联，但它可能会由眼科医生评估 COVID-19 患者的眼部症状，从而有助于诊断和预防传播。方法回顾性分析2020年3月至2020年5月期间巴吉亚塔拉医院收治的60例COVID-19患者的眼部表现、血液检查和逆转录聚合酶链反应（RT-PCR）的SARS-CoV -2 使用鼻咽和结膜拭子。结果 60 例临床确诊 COVID-19 患者中，中位年龄 58.36 岁（IQR：30-88 岁），男性 27 例（45%）。此外，29 名（48%）和 5 名（8%）患者的鼻咽拭子和结膜标本的 RT-PCR 检测结果分别为 SARS-CoV-2 阳性。在 60 名患者中，分别有 10 名（16%）和 3 名（5%）的眼部表现和 SARS-CoV-2 结膜和鼻咽拭子的 RT-PCR 阳性结果。结论 尽管泪液 RT-PCR 阳性率作为鼻咽拭子尚不明显，但 COVID-19 通过眼睛传播在生物学上是合理的。