The pursuit for the discovery of new and powerful synthetic methods to access high-value N-heterocycles has been at the forefront of organic chemistry research for more than a century. Considering the importance of N-scaffolds in modern science, over the past few decades, great research efforts have been made to develop efficient synthetic methods for the construction of nitrogen-rich molecules. Among many efforts, transition metal catalyzed denitrogenative annulation reaction has emerged as a cornerstone due to its innate versatility and wider scope of application.

中文翻译：

---

通过脱氮环化构建高价值 N-杂环的路线图

一个多世纪以来，寻求发现新的、强大的合成方法来获得高价值的N-杂环化合物一直处于有机化学研究的前沿。考虑到 N 支架在现代科学中的重要性，在过去的几十年中，人们做出了巨大的研究努力来开发有效的合成方法来构建富氮分子。在众多努力中，过渡金属催化的脱氮环化反应因其与生俱来的多功能性和更广泛的应用范围而成为基石。