Background. Despite approximately 95% primary cases of hypertension, secondary hypertension seems to be common with resistant forms. Notably, obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension and has a major characteristic of obesity. Irisin acts as a link between muscles and adipose tissues in obesity, playing an essential role in human blood pressure (BP) regulation. However, whether irisin is associated with secondary hypertension caused by OSA and how it takes effect essentially have not been elucidated. Purpose. To investigate the changes of irisin and its relationship with BP in OSA. Methods. 72 snoring patients finished Epworth Sleep Scale (ESS) evaluation before polysomnography (PSG). BP was the average of three brachial BP values by mercury sphygmomanometer. Serum irisin level was determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed by SPSS software. Results. Irisin was higher in the severe and quite severe group than that in control and nonsevere groups (). For BP, significant differences were found between the control group and the other three groups () and between the quite severe and the other three groups (). Positive correlations were found between irisin and apnea-hypopnea index (AHI), AHI and BP, and irisin level and BP. Negative correlations were between irisin and SpO₂ nadir and SpO₂ nadir and BP. Positive correlation still existed between AHI and irisin even after adjusting for some obesity-related variables. Conclusions. Irisin may serve as a potential biomarker for severity of OSA independently of obesity and imply the development of hypertension.

中文翻译：

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鸢尾素与阻塞性睡眠呼吸暂停患者的血压相关

背景。尽管大约 95% 为原发性高血压病例，但继发性高血压似乎常见于顽固性高血压。值得注意的是，阻塞性睡眠呼吸暂停 (OSA) 被认为是继发性高血压的常见原因，并且具有肥胖的主要特征。鸢尾素作为肥胖症患者肌肉和脂肪组织之间的纽带，在人体血压 (BP) 调节中发挥重要作用。然而，鸢尾素是否与 OSA 引起的继发性高血压有关，以及它如何发挥作用基本上尚未阐明。目的。探讨鸢尾素在OSA中的变化及其与血压的关系。方法. 72 名打鼾患者在多导睡眠图 (PSG) 之前完成了 Epworth 睡眠量表 (ESS) 评估。BP是水银血压计测得的三个肱动脉血压值的平均值。通过酶联免疫吸附试验（ELISA）测定血清鸢尾素水平。结果通过SPSS软件进行分析。结果。重度组和相当重度组的鸢尾素高于对照组和非重度组（）。对于血压，对照组与其他三组之间存在显着差异（）以及在相当严重和其他三组之间（）。鸢尾素与呼吸暂停低通气指数（AHI）、AHI与血压、鸢尾素水平与血压呈正相关。鸢尾素与SpO ₂最低点和_{SpO 2}最低点与BP 呈负相关。即使在调整了一些与肥胖相关的变量后，AHI 和鸢尾素之间仍然存在正相关。结论。鸢尾素可作为 OSA 严重程度的潜在生物标志物，与肥胖无关，并暗示高血压的发展。