Thyroid hormones are essential for fetal growth and the central nervous system development. Thyroid-stimulating hormone (TSH) is the key regulatory hormone. Their levels are quite dynamic in the perinatal period and are influenced by multiple factors. These factors should be taken into consideration during newborn screening. This study aimed to observe the impact of maternal and neonatal factors on neonatal TSH status. Neonatal TSH (nTSH) depicted a positive correlation with parity (p = 0.066) while negative correlation recorded with maternal blood haemoglobin (p = 0.007) among maternal factors. New-born length (p = 0.027) and birth weight (p < 0.001) exhibited a negative correlation with nTSH among neonatal factors. This study concludes that among all the maternal and neonatal factors, birth weight shows the most influence on nTSH. However, the effect may be compounded by other factors. As these risk elements rarely occur singly, it is often difficult to find the exposure which confer the risk on children. These factors should be considered while interpreting the result of the screening program.

中文翻译：

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对影响新生儿促甲状腺激素水平的母婴变量的详细观察研究

甲状腺激素对胎儿生长和中枢神经系统发育至关重要。促甲状腺激素 (TSH) 是关键的调节激素。它们的水平在围产期非常动态，并受多种因素的影响。在新生儿筛查时应考虑这些因素。本研究旨在观察孕产妇和新生儿因素对新生儿 TSH 状态的影响。新生儿 TSH (nTSH) 与胎次呈正相关 (p = 0.066)，而与母体血红蛋白 (p = 0.007) 记录的母体因素呈负相关。在新生儿因素中，新生儿身长 (p = 0.027) 和出生体重 (p < 0.001) 与 nTSH 呈负相关。本研究得出的结论是，在所有孕产妇和新生儿因素中，出生体重对 nTSH 的影响最大。然而，其他因素可能会加剧这种影响。由于这些风险因素很少单独发生，因此通常很难找到赋予儿童风险的接触。在解释筛选程序的结果时应考虑这些因素。