The immune system and the peripheral sensory nervous system communicate through hardwired and humoral routes using shared mediators and receptors. On the basis of studies on pain sensitivity in rodents, the immune system can be viewed as both friend and foe. T cells and macrophages enhance pain via proinflammatory mediators and promote pain resolution via anti-inflammatory mediators and endogenous opioids.

中文翻译：

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疼痛的免疫调节：朋友和敌人

免疫系统和外周感觉神经系统使用共享的介质和受体通过硬连线和体液途径进行交流。根据对啮齿动物疼痛敏感性的研究，免疫系统可以被视为朋友和敌人。T 细胞和巨噬细胞通过促炎介质增强疼痛，并通过抗炎介质和内源性阿片类药物促进疼痛消退。