当前位置: X-MOL 学术Cont. Lens Anterior Eye › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Crystalline lens thickness change is associated with axial length elongation and myopia progression in orthokeratology
Contact Lens & Anterior Eye ( IF 3.2 ) Pub Date : 2021-11-10 , DOI: 10.1016/j.clae.2021.101534
Zengying Wang 1 , Yifei Meng 1 , Zuocheng Wang 2 , Lili Hao 3 , Vania Rashidi 4 , Haiyan Sun 1 , Jun Zhang 1 , Xiaokun Liu 1 , Xuemin Duan 1 , Zhaocai Jiao 1 , Sufang Qie 1 , Zhipeng Yan 1
Affiliation  

Aims

Considering individual variability in regards to the effects of orthokeratology (ortho-k) on myopia progression and controversies regarding the precise underlying mechanism, the aim of this study was to investigate several ocular measurements associated with axial length (AL) growth in children wearing ortho-k lenses.

Methods

In this retrospective chart review, medical records of 53 Chinese children who wore ortho-k lenses over the course of 12 months were reviewed. Baseline variables included age at initiation of ortho-k wear, refractive error (spherical equivalent, SE), central corneal thickness (CCT), and flat and steep keratometry of corneal principal meridians. The change of anterior chamber depth (ACD) and the change of crystalline lens thickness (CLT) between baseline and the 12-month follow-up were also analyzed. The contributions of all analyzed variables to AL change were assessed using univariate and multivariate regression analyses.

Results

Initially, the results of paired t-test showed that CLT and AL were significantly increased after 12 months of ortho-k wear compared with that at baseline (P = 0.001 and < 0.001). The ACD did not change significantly after 12 months compared with that at baseline (P = 0.491). Subsequently, univariate analyses showed that a reduced rate of AL elongation was found in children who were older age at initiation of ortho-k wear (P = 0.028), had greater SE (higher degree of myopia) at baseline (p = 0.006), had thicker CCT at baseline (P = 0.04), and had greater increase of CLT (P = 0.001) in 12 months. At last, only greater SE (higher degree of myopia) and greater increase of CLT were associated with smaller increases of AL in multivariable analyses, (P = 0.003 and 0.001).

Conclusions

Both CLT and AL were significantly increased in children with overnight ortho-k wear after 12 months of follow-up. Greater baseline SE and greater increase of CLT were associated with less increase in AL during ortho-k wear in children with myopia.

更新日期:2021-11-10
down
wechat
bug