Gut colonization by colibactin-producing bacteria is associated with colorectal cancer. A mutational signature of this genotoxin in human cancer indicates causality but only partially accounts for cell transformation. Instead, the failure of adequately resolving DNA damage causes genomic aberrations and chromosomal instability, constituting the main starting point for colibactin-driven cancer.

中文翻译：

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机械解剖揭示了大肠杆菌素作为癌症的普遍诱变驱动因素

产生大肠杆菌素的细菌在肠道定植与结直肠癌有关。这种基因毒素在人类癌症中的突变特征表明存在因果关系，但仅部分解释了细胞转化。相反，未能充分解决 DNA 损伤会导致基因组畸变和染色体不稳定，构成大肠杆菌素驱动的癌症的主要起点。