Therapeutic options for metastatic prostate cancer patients are currently limited. In this issue of Cancer Cell, Kfoury et al. characterized the tumor and immune compartments of prostate cancer bone metastasis, revealing a mechanism of immunosuppression that involves infiltration with M2 macrophages and T cell exhaustion mediated by the CCL20-CCR6 axis.

中文翻译：

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对前列腺癌骨转移免疫抑制情况的罕见见解

目前，转移性前列腺癌患者的治疗选择有限。在本期《癌细胞》中，Kfoury 等人。描述了前列腺癌骨转移的肿瘤和免疫区室，揭示了一种免疫抑制机制，包括由 CCL20-CCR6 轴介导的 M2 巨噬细胞浸润和 T 细胞耗竭。