CD8 T cells are essential in controlling HBV infection. Viral control is dependent on efficient recognition of HBV-infected hepatocytes by CD8 T cells, which can induce direct lysis of infected hepatocytes. In addition, CD8 T cells produce interferon (IFN)-γ, which mediates noncytopathic viral clearance. Innate immunomodulators and HBV-targeted RNA interference (RNAi) are being developed to treat chronic hepatitis B (CHB), but may modify HBV antigen presentation and impact CD8 T-cell recognition, in addition to their primary mechanisms of action.

中文翻译：

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免疫调节和 RNA 干扰改变了乙型肝炎病毒特异性 CD8 T 细胞对感染的 HepG2-NTCP 的识别

CD8 T 细胞对于控制 HBV 感染至关重要。病毒控制依赖于 CD8 T 细胞对 HBV 感染的肝细胞的有效识别，这可以诱导感染肝细胞的直接裂解。此外，CD8 T 细胞产生干扰素 (IFN)-γ，它介导非细胞病变性病毒清除。先天免疫调节剂和 HBV 靶向 RNA 干扰 (RNAi) 正在开发用于治疗慢性乙型肝炎 (CHB)，但除了它们的主要作用机制外，它们可能会改变 HBV 抗原呈递并影响 CD8 T 细胞识别。