This review presents principles and novelties in the field of tissue optical clearing (TOC) technology, as well as application for optical monitoring of drug delivery and effective antimicrobial phototherapy. TOC is based on altering the optical properties of tissue through the introduction of immersion optical cleaning agents (OCA), which impregnate the tissue of interest. We also analyze various methods and kinetics of delivery of photodynamic agents, nanoantibiotics and their mixtures with OCAs into the tissue depth in the context of antimicrobial and antifungal phototherapy. In vitro and in vivo studies of antimicrobial phototherapies, such as photodynamic, photothermal plasmonic and photocatalytic, are summarized, and the prospects of a new TOC technology for effective killing of pathogens are discussed.

本综述介绍了组织光学清除 (TOC) 技术领域的原理和新颖性，以及在药物输送的光学监测和有效的抗菌光疗中的应用。TOC 基于通过引入浸入式光学清洁剂 (OCA) 来改变组织的光学特性，OCA 浸渍感兴趣的组织。我们还分析了在抗微生物和抗真菌光疗的背景下将光动力剂、纳米抗生素及其与 OCA 的混合物输送到组织深度的各种方法和动力学。体外和体内总结了光动力、光热等离子体和光催化等抗菌光疗法的研究，并讨论了有效杀灭病原体的新 TOC 技术的前景。