Jacaric acid, a conjugated linolenic acid (CLNA) present in jacaranda oil (JO), is considered a potent anticarcinogenic agent. Several studies have focused on its biological effects, but the metabolism once consumed is not clear yet. The aim of this work was to evaluate the effects of two different daily doses of JO on serum parameters and fatty acid (FA) profile of mice tissues after 4 weeks of feeding. No significant changes on body weight gain, food intake, or tissue weight were determined after 0.7 or 2 ml/kg of JO supplementation compared to control animals. Significantly lower blood low-density lipoproteins-cholesterol (20 mg/dl) and glucose (~147–148 mg/dl) levels were detected in both oil-treated groups compared to control (31.2 and 165 mg/dl, respectively). Moreover, jacaric acid was partially converted into cis9, trans11 conjugated linoleic acid (CLA) and thus further incorporated into tissues. Liver evidenced the highest total conjugated fatty acid content (1.1%–2.2%), followed by epididymal (0.7%–1.9%) and mesenteric (1.4%–1.8%) fat. Lower saturated and higher unsaturated fatty acid content was detected in both oil-treated groups compared to control. Our results support the safety of JO and its potential application with a functional or nutraceutical propose, by increasing human CLNA consumption and further availability of CLA.

中文翻译：

---

蓝花楹油给药可改善血清生物标志物和生物活性共轭脂肪酸的生物利用度，并改变小鼠组织的脂肪酸谱

蓝花楹酸是一种存在于蓝花楹油 (JO) 中的共轭亚麻酸 (CLNA)，被认为是一种有效的抗癌剂。几项研究都集中在它的生物效应上，但食用后的新陈代谢尚不清楚。这项工作的目的是评估两种不同每日剂量的 JO 对喂养 4 周后小鼠组织的血清参数和脂肪酸 (FA) 谱的影响。与对照动物相比，在 0.7 或 2 ml/kg 的 JO 补充剂后，体重增加、食物摄入或组织重量没有显着变化。与对照组相比（分别为 31.2 和 165 mg/dl），在两个油处理组中检测到显着降低的血液低密度脂蛋白胆固醇（20 mg/dl）和葡萄糖（~147-148 mg/dl）水平。此外，jacaric acid 部分转化为cis如图9所示，反式11共轭亚油酸（CLA）并因此进一步掺入组织中。肝脏的总共轭脂肪酸含量最高 (1.1%–2.2%)，其次是附睾 (0.7%–1.9%) 和肠系膜 (1.4%–1.8%) 脂肪。与对照组相比，在两个油处理组中检测到较低的饱和脂肪酸和较高的不饱和脂肪酸含量。我们的结果通过增加人类 CLNA 的消耗和 CLA 的进一步可用性来支持 JO 的安全性及其在功能或营养保健方面的潜在应用。