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Shining light on dark selection in healthy human tissues
Nature Genetics ( IF 30.8 ) Pub Date : 2021-11-04 , DOI: 10.1038/s41588-021-00959-z
Benjamin Werner 1
Affiliation  

The genomes of cells across human tissues are riddled by changes to their DNA1–3. Many of these mutations do not alter the properties of a cell, and are neutral passengers. However, a small proportion can change a cell’s fitness, and increase or decrease the progeny that originate from the mutated cell4. How many of these alterations under positive selection (drivers) exist in total is unknown. Whether the current list of drivers is almost complete, or whether large proportions of positively selected drivers in the human genome remain undetected is yet to be determined.

中文翻译:

照亮健康人体组织中的黑暗选择

人体组织中的细胞基因组充满了 DNA1-3 的变化。许多这些突变不会改变细胞的特性,并且是中性的乘客。然而,一小部分可以改变细胞的适应度,并增加或减少源自突变细胞的后代。在正选择(驱动程序)下总共存在多少这些改变是未知的。目前的驱动因素列表是否几乎完整,或者人类基因组中大部分积极选择的驱动因素是否仍未被发现,还有待确定。
更新日期:2021-11-05
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