Purpose

This study aimed to develop a niosome-encapsulated clindamycin phosphate (CMP) formulation for topical delivery.

Methods

The possibility of encapsulation of this antibiotic in niosomes, its stability, cytotoxicity, and antibacterial capability were evaluated. Diverse combinations of sorbitan esters and their ethoxylated derivatives with cholesterol were used to prepare the lipid vesicles.

Results

This series of niosomes had high physical stability depicted as unchanged size distribution curves during 6-month storage. Formulations composed of Span 60 and Tween 60 in combination with 30 mol% of cholesterol exhibited the highest encapsulation efficiency (47.14%). Minimal inhibitory concentration of the niosomal CMP against Staphylococcus aureus was higher than free CMP. Slow and biphasic release profile of CMP was also shown.

Conclusions

These results indicate that niosomes can be used as stable carriers for topical delivery of CMP in acne.

中文翻译：

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脱水山梨糖醇酯及其乙氧基化衍生物制备稳定的克林霉素磷酸酯类脂质体

目的

本研究旨在开发一种用于局部给药的 niosome 包裹的克林霉素磷酸酯 (CMP) 制剂。

方法

评估了这种抗生素在 niosomes 中封装的可能性、其稳定性、细胞毒性和抗菌能力。脱水山梨糖醇酯及其乙氧基化衍生物与胆固醇的多种组合用于制备脂质囊泡。

结果

这一系列的 niosomes 具有很高的物理稳定性，在 6 个月的储存期间显示为不变的尺寸分布曲线。由 Span 60 和 Tween 60 与 30 mol% 胆固醇组合组成的制剂表现出最高的包封效率 (47.14%)。Niosomal CMP 对金黄色葡萄球菌的最小抑制浓度高于游离 CMP。还显示了 CMP 的缓慢和双相释放曲线。

结论

这些结果表明，niosomes 可用作稳定的载体，用于在痤疮中局部递送 CMP。