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The efficacy of chlorine-based disinfectants against planktonic and biofilm bacteria for decentralised point-of-use drinking water
npj Clean Water ( IF 11.4 ) Pub Date : 2021-11-04 , DOI: 10.1038/s41545-021-00139-w
Gillian E. Clayton 1 , Robin M. S. Thorn 1 , Darren M. Reynolds 1
Affiliation  

Chlorine solutions are used extensively for the production of biologically safe drinking water. The capability of point-of-use [POU] drinking water treatment systems has gained interest in locations where centralised treatment systems and distribution networks are not practical. This study investigated the antimicrobial and anti-biofilm activity of three chlorine-based disinfectants (hypochlorite ions [OCl-], hypochlorous acid [HOCl] and electrochemically activated solutions [ECAS]) for use in POU drinking water applications. The relative antimicrobial activity was compared within bactericidal suspension assays (BS EN 1040 and BS EN 1276) using Escherichia coli. The anti-biofilm activity was compared utilising established sessile Pseudomonas aeruginosa within a Centre for Disease Control [CDC] biofilm reactor. HOCl exhibited the greatest antimicrobial activity against planktonic E. coli at >50 mg L−1 free chlorine, in the presence of organic loading (bovine serum albumen). However, ECAS exhibited significantly greater anti-biofilm activity compared to OCl- and HOCl against P. aeruginosa biofilms at ≥50 mg L−1 free chlorine. Based on this evidence disinfectants where HOCl is the dominant chlorine species (HOCl and ECAS) would be appropriate alternative chlorine-based disinfectants for POU drinking water applications.



中文翻译:

氯基消毒剂对分散式使用点饮用水中浮游细菌和生物膜细菌的抑制作用

氯溶液广泛用于生产生物安全饮用水。使用点 [POU] 饮用水处理系统的能力在集中处理系统和分配网络不实用的地方引起了人们的兴趣。本研究调查了用于 POU 饮用水应用的三种氯基消毒剂(次氯酸根离子 [OCl - ]、次氯酸 [HOCl] 和电化学活化溶液 [ECAS])的抗菌和抗生物膜活性。在使用大肠杆菌的杀菌悬浮液测定(BS EN 1040 和 BS EN 1276)中比较了相对抗微生物活性。利用已建立的无柄铜绿假单胞菌比较抗生物膜活性在疾病控制中心 [CDC] 生物膜反应器内。在有机负载(牛血清蛋白)存在下,HOCl在 >50 mg L -1游离氯时对浮游大肠杆菌表现出最大的抗菌活性。然而,与 OCl -和 HOCl相比,ECAS在 ≥50 mg L -1游离氯时对铜绿假单胞菌生物膜表现出显着更高的抗生物膜活性。基于这一证据,以 HOCl 为主要氯种类的消毒剂(HOCl 和 ECAS)将是 POU 饮用水应用的合适替代氯基消毒剂。

更新日期:2021-11-05
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