Background

Although many studies reported a close relationship between depression and Alzheimer’s disease (AD), the underlying pathophysiological mechanism remains unclear. The present study aimed to investigate the mechanism of AD and major depressive disorder (MDD). Method: The datasets were downloaded from the Gene Expression Omnibus. After screening differentially expressed genes (DEGs), gene ontology and pathway analysis were performed and protein–protein interaction, TF-target gene, and miRNA-target gene networks were established. Results: 171 DEGs of AD-related datasets and 79 DEGs shared by AD and MDD were detected. Functional analysis revealed that AD and MDD common genes were significantly enriched in circadian entrainment and long-term depression signaling pathways. Five hub genes were identified after construction of networks and validation of hub gene signatures. In conclusion, DYNC1H1, MAPRE3, TTBK2, ITGB1, and WASL may be potential targets for the diagnosis and treatment of AD and MDD.

背景

尽管许多研究报告了抑郁症与阿尔茨海默病 (AD) 之间的密切关系，但其潜在的病理生理机制仍不清楚。本研究旨在探讨 AD 和重度抑郁症 (MDD) 的发病机制。方法：数据集下载自 Gene Expression Omnibus。筛选差异表达基因（DEGs）后，进行基因本体和通路分析，建立蛋白质-蛋白质相互作用、TF-靶基因和miRNA-靶基因网络。结果：检测到 171 个 AD 相关数据集和 79 个 AD 和 MDD 共享的 DEG。功能分析表明，AD 和 MDD 共同基因在昼夜节律和长期抑郁信号通路中显着富集。在构建网络和验证集线器基因特征后，确定了五个集线器基因。总之，DYNC1H1、MAPRE3、TTBK2、ITGB1和WASL可能是诊断和治疗AD和MDD的潜在靶点。