当前位置: X-MOL 学术Cell › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Kr-h1 maintains distinct caste-specific neurotranscriptomes in response to socially regulated hormones
Cell ( IF 64.5 ) Pub Date : 2021-11-04 , DOI: 10.1016/j.cell.2021.10.006
Janko Gospocic 1 , Karl M Glastad 2 , Lihong Sheng 2 , Emily J Shields 1 , Shelley L Berger 3 , Roberto Bonasio 2
Affiliation  

Behavioral plasticity is key to animal survival. Harpegnathos saltator ants can switch between worker and queen-like status (gamergate) depending on the outcome of social conflicts, providing an opportunity to study how distinct behavioral states are achieved in adult brains. Using social and molecular manipulations in live ants and ant neuronal cultures, we show that ecdysone and juvenile hormone drive molecular and functional differences in the brains of workers and gamergates and direct the transcriptional repressor Kr-h1 to different target genes. Depletion of Kr-h1 in the brain caused de-repression of “socially inappropriate” genes: gamergate genes were upregulated in workers, whereas worker genes were upregulated in gamergates. At the phenotypic level, loss of Kr-h1 resulted in the emergence of worker-specific behaviors in gamergates and gamergate-specific traits in workers. We conclude that Kr-h1 is a transcription factor that maintains distinct brain states established in response to socially regulated hormones.



中文翻译:

Kr-h1 维持独特的种姓特异性神经转录组以响应社会调节的激素

行为可塑性是动物生存的关键。Harpegnathos 跳跃者蚂蚁可以根据社会冲突的结果在工蚁和蚁后状态之间切换 (gamergate),这为研究成年大脑如何实现不同的行为状态提供了机会。在活体蚂蚁和蚂蚁神经元培养物中使用社会和分子操作,我们表明蜕皮激素和保幼激素驱动工蚁和游戏门的大脑中的分子和功能差异,并将转录抑制因子 Kr-h1 导向不同的靶基因。大脑中 Kr-h1 的耗尽导致“社会不适当”基因的去抑制:gamergate 基因在工人中上调,而工人基因在 gamergates 中上调。在表型水平上,Kr-h1 的缺失导致在玩家门中出现特定于工人的行为和在工人中出现特定于玩家门的特征。

更新日期:2021-11-11
down
wechat
bug