High-grade serous ovarian cancers (HGSOCs) exhibit limited response to immune checkpoint blockade. In a new study in Cancer Cell, Duraiswamy et al. highlight intratumoral CD28 co-stimulation by myeloid-antigen-presenting cells as a key mechanism required for activation of programmed cell death receptor 1 (PD-1)⁺ tumor-infiltrating T lymphocytes during PD-1 blockade in HGSOC.

中文翻译：

---

振兴卵巢癌中功能失调的 T 细胞：CD28 是杀死的许可证

高级别浆液性卵巢癌 (HGSOCs) 对免疫检查点阻断反应有限。在癌细胞的一项新研究中，Duraiswamy 等人。突出显示髓样抗原呈递细胞的肿瘤内 CD28 共刺激是HGSOC 中 PD-1 阻断期间激活程序性细胞死亡受体 1 (PD-1) ⁺肿瘤浸润性 T 淋巴细胞所需的关键机制。