Herein, a hexafluoroisopropanol (HFIP)-promoted Wolff rearrangement reaction was developed, delivering various α,α-disubstituted carboxylic acid derivatives in good to excellent yields. In this reaction, α-diazoketone could be activated using HFIP under mild conditions via hydrogen bonding between hydroxyl and carbonyl groups.

中文翻译：

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在环境条件下通过沃尔夫重排反应无催化剂合成 α,α-二取代羧酸衍生物

在此，开发了六氟异丙醇 (HFIP) 促进的沃尔夫重排反应，以良好到优异的产率提供各种 α,α-二取代羧酸衍生物。在该反应中，α-重氮酮可以通过羟基和羰基之间的氢键在温和条件下使用 HFIP 活化。