PURPOSE

To assess the clinical utility of swept-source optical coherence tomography angiography (SS-OCTA) in detecting optic disc microvasculature dropout (MvD-D) in primary open-angle glaucoma (POAG) eyes.

DESIGN

Cross-sectional study.

METHODS

The study enrolled 197 eyes of 197 patients with POAG with acceptable-quality SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec) images. A whole-signal-mode 6.0- × 6.0-mm optic disc cube was obtained with projection artifact removal. Three groups were categorized: no MvD-D (group 1), MvD-D (group 2, complete loss of microvasculature within the optic disc), and indiscernible MvD-D (group 3, poor visualization of the anterior lamina cribrosa [LC]).

RESULTS

There were 82 (42.1%) and 81 (41.5%) eyes categorized as no MvD-D (group 1) and MvD-D (group 2), respectively. The remaining 32 eyes (16.4%), categorized as indiscernible MvD-D (group 3), had a significantly smaller anterior scleral canal opening (ASCO) area (P < .05). Group 2 had significantly worse visual field (VF) mean deviation (MD), thinner average retinal nerve fiber layer (RNFL), higher prevalence of focal LC defect, and parapapillary deep-layer microvasculature dropout (MvD-P) than the other 2 groups (P < .05). In the multivariable logistic regression analysis, higher prevalence of focal LC defect (odds ratio, 46.91; P < .001) and MvD-P (odds ratio, 48.94; P < .001) remained as factors associated with MvD-D.

CONCLUSIONS

The presence of MvD-D could be well determined by SS-OCTA in eyes with POAG. MvD-P and focal LC defects were strongly associated with MvD-D. This suggests that SS-OCTA can serve as a useful tool in detecting optic disc microvasculature damage.

中文翻译：

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扫描源光学相干断层扫描血管造影检测青光眼视盘微血管脱落

目的

评估扫描源光学相干断层扫描血管造影 (SS-OCTA) 在检测原发性开角型青光眼 (POAG) 眼视盘微血管脱落 (MvD-D) 中的临床效用。

设计

横断面研究。

方法

该研究纳入了 197 名 POAG 患者的 197 只眼，这些患者具有可接受质量的 SS-OCTA（PLEX Elite 9000；Carl Zeiss Meditec）图像。通过投影伪影去除获得了全信号模式 6.0-×6.0-mm 视盘立方体。分为三组：无 MvD-D（第 1 组）、MvD-D（第 2 组，视盘内微血管完全丧失）和难以辨认的 MvD-D（第 3 组，前筛板 [LC] 的可视性差） ).

结果

分别有 82 (42.1%) 和 81 (41.5%) 只眼睛被归类为无 MvD-D（第 1 组）和 MvD-D（第 2 组）。其余 32 只眼 (16.4%) 被归类为难以分辨的 MvD-D（第 3 组），前巩膜管开口 (ASCO) 面积明显较小 ( P < .05)。第 2 组的视野 (VF) 平均偏差 (MD)、平均视网膜神经纤维层 (RNFL) 较薄、局灶性 LC 缺损率较高以及乳头旁深层微血管脱落 (MvD-P) 明显较其他 2 组差( P < .05)。在多变量逻辑回归分析中，较高的局灶性 LC 缺陷（比值比，46.91；P < .001）和 MvD-P（比值比，48.94；P <.001）仍然是与 MvD-D 相关的因素。

结论

MvD-D 的存在可以通过 SS-OCTA 在具有 POAG 的眼睛中很好地确定。MvD-P 和局灶性 LC 缺陷与 MvD-D 密切相关。这表明 SS-OCTA 可以作为检测视盘微血管损伤的有用工具。