Internalizing problems (e.g., depression, anxiety) and substance use are common among young people and often co-occur. However, youths face myriad barriers to access needed treatment, and existing evidence-based interventions tend to focus on internalizing problems or substance use, rather than both simultaneously. Brief interventions that target both problems may, therefore, be an efficient and accessible resource for alleviating youth difficulties; however, this possibility has been insufficiently evaluated. This systematic review evaluated the intervention characteristics and quality of six studies spanning 2015 to 2019 that examined intervention effects on internalizing and substance use outcomes. Based on independent calculations and author reports (respectively), 3–4 interventions significantly reduced youth internalizing symptoms; 3–5 reduced youth substance use; and 2–3 reduced symptoms in both domains. All six interventions identified substance use as a primary target. Four interventions were administered by interventionists to youths in inpatient, outpatient, primary care, or school settings. The remaining two studies delivered content through voicemail messages or an online design. Interventions ranged from ~ 15 to 240 min. Results highlight the sparsity and heterogeneity of youth-focused brief interventions that have evaluated program effects on both internalizing problems and substance use outcomes, suggesting a clear need for integrated supports that are also designed for accessibility. Future investigations of brief youth-focused interventions should assess program effects on both internalizing and substance use outcomes; examine mechanisms driving the varied efficacy of identified interventions; and create, refine, and test interventions with potential to address co-occurring internalizing problems and substance use in young people.

内化问题（如抑郁、焦虑）和药物滥用在年轻人中很常见，并且经常同时发生。然而，青少年在获得所需治疗方面面临着无数障碍，现有的循证干预往往侧重于内化问题或药物使用，而不是同时关注两者。因此，针对这两个问题的简短干预可能是缓解青年困难的有效且可获取的资源；然而，这种可能性尚未得到充分评估。本系统评价评估了 2015 年至 2019 年间六项研究的干预特征和质量，这些研究检查了干预对内化和物质使用结果。根据独立计算和作者报告（分别），3-4 项干预措施显着减少了青少年内化症状；3-5 减少青少年物质使用；和 2-3 减轻了两个领域的症状。所有六项干预措施都将物质使用确定为主要目标。干预专家对住院、门诊、初级保健或学校环境中的青少年实施了四项干预措施。其余两项研究通过语音邮件消息或在线设计传递内容。干预范围为~ 15 至 240 分钟。结果突出了以青年为重点的简短干预措施的稀疏性和异质性，这些干预措施评估了项目对两者的影响内化问题和物质使用结果，表明明确需要为可访问性而设计的综合支持。未来对以青年为重点的简短干预措施的调查应评估项目对内化和物质使用结果的影响；检查驱动已确定干预措施不同功效的机制；并创建、改进和测试有可能解决年轻人内化问题和物质使用的潜在干预措施。