Effects of luseogliflozin on estimated plasma volume in patients with heart failure with preserved ejection fraction,ESC Heart Failure

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Effects of luseogliflozin on estimated plasma volume in patients with heart failure with preserved ejection fraction
ESC Heart Failure ( IF 3.8 ) Pub Date : 2021-11-03 , DOI: 10.1002/ehf2.13683
Mitsutaka Nakashima ₁ , Toru Miyoshi ₁ , Kentaro Ejiri _{1,

2} , Hajime Kihara ₃ , Yoshiki Hata ₄ , Toshihiko Nagano ₅ , Atsushi Takaishi ₆ , Hironobu Toda _{1,

7} , Seiji Nanba ₈ , Yoichi Nakamura ₉ , Satoshi Akagi ₁₀ , Satoru Sakuragi ₁₁ , Taro Minagawa ₁₂ , Yusuke Kawai ₁₃ , Nobuhiro Nishii _{1,

14} , Soichiro Fuke ₁₅ , Masaki Yoshikawa ₁₆ , Kazufumi Nakamura ₁ , Hiroshi Ito ₁ ,

Affiliation

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Department of Internal Medicine, Tamano City Hospital, Okayama, Japan.
Department of Internal Medicine, Kihara Cardiovascular Clinic, Asahikawa, Japan.
Department of Cardiology, Minamino Cardiovascular Hospital, Hachioji, Japan.
Department of Internal Medicine, Iwasa Hospital, Gifu, Japan.
Department of Cardiology, Mitoyo General Hospital, Kanonji, Japan.
Department of Internal Medicine, Okayama East Neurosurgery Hospital, Okayama, Japan.
Department of Cardiology, Okayama Rosai Hospital, Okayama, Japan.
Department of Cardiovascular Medicine, Specified Clinic of Soyokaze CardioVascular Medicine and Diabetes Care, Matsuyama, Japan.
Department of Internal Medicine, Akaiwa Medical Association Hospital, Okayama, Japan.
Department of Cardiovascular Medicine, Iwakuni Clinical Center, Iwakuni, Japan.
Department of Internal Medicine, Minagawa Cardiovascular Clinic, Gifu, Japan.
Department of Cardiovascular Medicine, Okayama City Hospital, Okayama, Japan.
Department of Internal Medicine, Yoshinaga Hospital, Bizen, Japan.
Department of Cardiovascular Medicine, Japanese Red Cross Okayama Hospital, Okayama, Japan.
Department of Cardiology, Fukuyama City Hospital, Fukuyama, Japan.

Sodium glucose co-transporter 2 inhibitors have diuretic effects in both patients with glycosuria and with natriuresis. We sought to assess the effect of luseogliflozin on estimated plasma volume (ePV) in patients with type 2 diabetes and heart failure with preserved ejection fraction (HFpEF).

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