To evaluate associations between diabetic peripheral neuropathy (DPN) and urological complications in men and women with type 1 diabetes (T1D).

Measurements of DPN at Epidemiology of Diabetes Intervention and Complications (EDIC) years 1, 14, and 17 and urological complications at EDIC year 17 were examined in 635 men (mean age 51.6 years, diabetes duration 29.5 years) and 371 women (mean age 50.6 years, diabetes duration 29.8 years) enrolled in the Diabetes Control and Complications Trial (DCCT)/EDIC study. DPN was defined by symptoms, signs, and abnormal electrophysiology or by abnormal Michigan Neuropathy Screening Instrument (MNSI) examination or questionnaire scores.

Erectile dysfunction (ED) in combination with lower urinary tract symptoms (LUTS) was reported in 15% of men and female sexual dysfunction (FSD), LUTS, and urinary incontinence (UI) in 16% of women. Adjusted for age, drinking status, BMI, depression, DCCT/EDIC time-weighted mean HbA_1c, microalbuminuria, hypertension, triglycerides, and statin medication use, the odds of reporting ED and LUTS versus no ED or LUTS at EDIC year 17 were 3.52 (95% CI 1.69, 7.31) times greater in men with confirmed DPN at EDIC year 13/14 compared to men without confirmed DPN. Compared to men without DPN, men with DPN based on abnormal MNSI examination or questionnaire scores had significantly higher odds of reporting ED and LUTS vs. no ED or LUTS at EDIC year 17. There were no significant differences in DPN between women reporting both FSD and LUTS/UI compared with those without FSD or LUTS/UI at EDIC year 17.

In long-standing T1D, DPN is associated with the later development of urological complications in men.

评估 1 型糖尿病 (T1D) 男性和女性糖尿病周围神经病变 (DPN) 与泌尿系统并发症之间的关联。

在 635 名男性（平均年龄 51.6 岁，糖尿病病程 29.5 年）和 371 名女性（平均年龄 50.6 岁）中检查了糖尿病干预和并发症流行病学 (EDIC) 第 1、14 和 17 年的 DPN 测量值以及 EDIC 第 17 年的泌尿系统并发症年，糖尿病病程 29.8 年）参加了糖尿病控制和并发症试验 (DCCT)/EDIC 研究。DPN 由症状、体征和异常电生理学或异常密歇根神经病变筛查仪 (MNSI) 检查或问卷评分定义。

据报道，15% 的男性患有勃起功能障碍 (ED) 并伴有下尿路症状 (LUTS)，16% 的女性患有性功能障碍 (FSD)、LUTS 和尿失禁 (UI)。根据年龄、饮酒状况、BMI、抑郁症、DCCT/EDIC 时间加权平均 HbA _{1c进行调整}、微量白蛋白尿、高血压、甘油三酯和他汀类药物的使用，在 EDIC 第 17 年报告 ED 和 LUTS 与没有 ED 或 LUTS 的几率是 3.52 (95% CI 1.69, 7.31) 倍，在 EDIC 第 13 年确诊为 DPN 的男性/ 14 与未确认 DPN 的男性相比。与没有 DPN 的男性相比，在 EDIC 17 年时，基于异常 MNSI 检查或问卷得分的 DPN 男性报告 ED 和 LUTS 的几率显着高于没有 ED 或 LUTS 的男性。报告 FSD 和女性之间的 DPN 没有显着差异在 EDIC 第 17 年，LUTS/UI 与没有 FSD 或 LUTS/UI 的人相比。

在长期存在的 T1D 中，DPN 与男性泌尿系统并发症的后期发展有关。