ABSTRACT

Purpose

We describe a case of bullous keratopathy complicated with cytomegalovirus (CMV) corneal endotheliitis that was successfully treated with ripasudil eye drops.

Methods

A retrospective case report.

Results

A 65-year-old female patient diagnosed with CMV-associated anterior uveitis in the right eye was referred to us when anterior uveitis recurred with bullous keratopathy. Initial best-corrected visual acuity (BCVA) was 0.4 (decimal visual acuity). Her condition did not improve with anti-CMV treatment, and BCVA decreased to 0.07. At this point, intraocular pressure (IOP) was 20 mmHg, and ripasudil eye drops were started for IOP control. After 1 month, not only had IOP decreased to 14 mm Hg but the condition of the corneal edema had also improved. The central corneal thickness decreased to a normal level, and the BCVA recovered to 0.8.

Conclusion

Ripasudil eye drops not only lower IOP in patients with CMV corneal endotheliitis but may also have the potential to treat bullous keratopathy.

中文翻译：

---

利帕舒地尔滴眼液改善大疱性角膜病变并发巨细胞病毒性角膜内皮炎：一例报告

摘要

目的

我们描述了一个大疱性角膜病变并发巨细胞病毒 (CMV) 角膜内皮炎的病例，该病例用利帕舒地尔滴眼液成功治疗。

方法

回顾性病例报告。

结果

一位 65 岁的女性患者被诊断为右眼 CMV 相关性前葡萄膜炎，当前葡萄膜炎复发并伴有大疱性角膜病变时被转诊给我们。初始最佳矫正视力 (BCVA) 为 0.4（小数视力）。抗 CMV 治疗后她的病情没有改善，BCVA 降至 0.07。此时，眼压（IOP）为20mmHg，开始使用利帕舒地尔滴眼液控制眼压。1个月后，不仅眼压下降到14mmHg，角膜水肿的情况也有所好转。中央角膜厚度下降至正常水平，BCVA恢复至0.8。

结论

Ripasudil 滴眼液不仅可以降低 CMV 角膜内皮炎患者的眼压，还可能具有治疗大泡性角膜病变的潜力。