Cardiac amyloidosis (CA) is an underdiagnosed form of restrictive cardiomyopathy leading to a rapid progression into heart failure. Evaluation of CA requires a multimodality approach making use of echocardiography, cardiac magnetic imaging, and nuclear imaging. Technetium (Tc)-labeled cardiac scintigraphy has witnessed a resurgence in its application for the workup of CA. Advancements in disease-modifying therapies have fueled the rapid adoption of cardiac scintigraphy using bone tracers and the need for transformative novel studies. The goal of this review is to present diagnostic utility, currently recommended protocols, as well as a glimpse into the rapid evolution of Tc-labeled cardiac scintigraphy in the diagnosis of CA.

心脏淀粉样变性 (CA) 是一种未得到充分诊断的限制性心肌病，可导致快速进展为心力衰竭。CA 的评估需要使用超声心动图、心脏磁成像和核成像的多模式方法。锝 (Tc) 标记的心脏闪烁显像见证了其在 CA 检查中的应用的复苏。疾病改善疗法的进步推动了使用骨示踪剂的心脏闪烁扫描法的迅速采用，以及对变革性新研究的需求。本综述的目的是介绍诊断实用性、目前推荐的方案，以及一瞥 Tc 标记的心脏闪烁显像在 CA 诊断中的快速发展。