Dual-modal ultrasound (US) and photoacoustic (PA) imaging has tremendous advantages in biomedical applications, such as pharmacokinetics, cancer screening, and imaging-guided therapy. Compared with ring-shaped arrays, a linear piezoelectric transducer array applies to more anatomical sites and has been widely used in US/PA imaging. However, the linear array may limit the imaging quality due to narrow bandwidth, partial detection view, or sparse spatial sampling. To meet clinic demand of high-quality US/PA imaging with the linear transducer, we develop dual-modal wide-beam harmonic ultrasound (WBHUS) and photoacoustic computed tomography at video rate. The harmonic US imaging employs pulse phase inversion to reduce clutters and improve spatial resolution. Wide-beam US transmission can shorten the scanning times by 267% and enables a 20-Hz imaging rate, which can minimize motion artifacts in in vivo imaging. The harmonic US imaging does not only provide accurate anatomical references for locating PA features but also reduces artifacts in PA images. The improved image quality allows us to acquire high-resolution anatomical structures in deep tissue without labeling. The fast-imaging speed enables visualizing interventional procedures and monitoring the pulsations of the thoracic aorta and radial artery in real-time. The video-rate dual-modal harmonic US and single-shot PA computed tomography use a clinical-grade linear-array transducer and thus can be readily implemented in clinical US imaging.

中文翻译：

---

视频速率双模宽波束谐波超声和光声计算机断层扫描

双模超声 (US) 和光声 (PA) 成像在生物医学应用中具有巨大优势，例如药代动力学、癌症筛查和成像引导治疗。与环形阵列相比，线性压电换能器阵列适用于更多的解剖部位，并已广泛应用于 US/PA 成像。然而，由于窄带宽、部分检测视图或稀疏空间采样，线性阵列可能会限制成像质量。为了满足使用线性换能器进行高质量 US/PA 成像的临床需求，我们开发了双模宽波束谐波超声 (WBHUS) 和视频速率的光声计算机断层扫描。谐波 US 成像采用脉冲相位反转来减少杂波并提高空间分辨率。体内成像。谐波超声成像不仅为定位 PA 特征提供准确的解剖参考，而且还减少了 PA 图像中的伪影。改进的图像质量使我们能够在没有标记的情况下获取深层组织中的高分辨率解剖结构。快速的成像速度使介入程序可视化并实时监测胸主动脉和桡动脉的搏动。视频速率双模谐波 US 和单次 PA 计算机断层扫描使用临床级线性阵列传感器，因此可以很容易地在临床 US 成像中实施。