The therapy of tumor recurrence resulting from surgical resection of osteosarcoma is still a significant challenge for clinicians. In this study, we designed curcumin (CM) and indocyanine green (ICG) co-loaded poly(L-lactic acid) (PLLA) (PLLA-CM-ICG) composite microparticles, combining photothermal therapy with chemotherapy to enhance osteosarcoma therapy synergistically. PLLA-CM-ICG microparticles of sizes of (838.3 ± 5.4) nm were prepared by solution-enhanced dispersion by a supercritical CO₂ process. ICG in the PLLA-CM-ICG microparticles was more stable than free ICG. The PLLA-CM-ICG microparticles displayed pH- and near-infrared (NIR)-responsive CM release behavior. Moreover, NIR irradiation improved the anticancer activity of the PLLA-CM-ICG microparticles at a concentration of 250 μg/mL on MG-63 cells. Therefore, PLLA-CM-ICG microparticles could be employed as promising drug delivery systems for synergic photothermo-chemotherapy in osteosarcoma treatment.

骨肉瘤手术切除引起的肿瘤复发的治疗仍然是临床医生面临的重大挑战。在这项研究中，我们设计了姜黄素（CM）和吲哚菁绿（ICG）共载聚（L-乳酸）（PLLA）（PLLA-CM-ICG）复合微粒，将光热疗法与化学疗法相结合，以协同增强骨肉瘤的治疗效果。通过超临界 CO ₂溶液增强分散制备尺寸为 (838.3 ± 5.4) nm 的 PLLA-CM-ICG 微粒过程。PLLA-CM-ICG 微粒中的 ICG 比游离 ICG 更稳定。PLLA-CM-ICG 微粒表现出 pH 和近红外 (NIR) 响应的 CM 释放行为。此外，NIR 照射提高了浓度为 250 μg/mL 的 PLLA-CM-ICG 微粒对 MG-63 细胞的抗癌活性。因此，PLLA-CM-ICG 微粒可作为有前景的药物递送系统，用于骨肉瘤治疗中的协同光热化疗。