Distinct structural and dynamic components of portal hypertension in different animal models and human liver disease etiologies,Hepatology

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Distinct structural and dynamic components of portal hypertension in different animal models and human liver disease etiologies
Hepatology ( IF 13.5 ) Pub Date : 2021-10-30 , DOI: 10.1002/hep.32220
Philipp Königshofer _{1,

2,

3,

4,

5} , Benedikt Silvester Hofer _{1,

2,

3,

4} , Ksenia Brusilovskaya _{1,

2,

3,

4,

5} , Benedikt Simbrunner _{1,

2,

3,

4,

5,

6} , Oleksandr Petrenko _{1,

2,

3,

4,

5} , Katharina Wöran ₇ , Merima Herac ₇ , Judith Stift ₇ , Katharina Lampichler ₈ , Gerald Timelthaler ₉ , David Bauer _{1,

2,

6} , Lukas Hartl _{1,

2,

6} , Bernhard Robl ₁₀ , Maria Sibila ₁₀ , Bruno K Podesser ₁₁ , Georg Oberhuber ₁₂ , Philipp Schwabl _{1,

2,

3,

4,

5,

6} , Mattias Mandorfer _{1,

6} , Michael Trauner ₁ , Thomas Reiberger _{1,

2,

3,

4,

5,

6}

Affiliation

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Vienna Experimental Hepatic Hemodynamic Lab (HEPEX), Medical University of Vienna, Vienna, Austria.
Christian Doppler Laboratory for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Vienna, Austria.
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Vienna Hepatic Hemodynamic Laboratoy, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Department of Pathology, Medical University of Vienna, Vienna, Austria.
Department of Radiology and Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
The Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Center for Biomedical Research, Medical University of Vienna, Vienna, Austria.
INNPATH, Institute of Pathology, University Hospital of Innsbruck, Innsbruck, Austria.

Liver fibrosis is the static and main (70%-80%) component of portal hypertension (PH). We investigated dynamic components of PH by a three-dimensional analysis based on correlation of hepatic collagen proportionate area (CPA) with portal pressure (PP) in animals or HVPG in patients.

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