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Therapy response assessment of non-small cell lung cancer using dual-energy computed tomography iodine map
Journal of X-Ray Science and Technology ( IF 3 ) Pub Date : 2021-10-26 , DOI: 10.3233/xst-210989
Lei Zhao 1 , Lijuan Liu 2 , Haiyan Zhao 3 , Jiaqi Bao 4 , Yana Dou 5 , Zhenxing Yang 1 , Yang Lin 5 , Zhenting Sun 1 , Lingxin Meng 1 , Li Yan 6 , Aishi Liu 1
Affiliation  

OBJECTIVE:To investigate feasibility of the quantitative parameters of dual-energy computed tomography (DECT) to assess therapy response in advanced non-small cell lung cancer (NSCLC) compared with the traditional enhanced CT parameters based on the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines. METHODS:Forty-five patients with unresectable locally advanced NSCLC who underwent DECT before and after chemotherapy or concurrent chemoradiotherapy (cCRT) were prospectively enrolled. By comparing baseline studies with follow-up, patients were divided into two groups according to RECIST guidelines as follows: disease control (DC, including partial response and stable disease) and progressive disease (PD). The diameter (D), attenuation, iodine concentration and normalized iodine concentration of arterial and venous phases (ICA, ICv, NICA, NICv) and the percentage of these changes pre- and post-therapy were measured and calculated. The Pearson correlation was used to analyze correlation between various quantitative parameters. The receiver operating characteristic (ROC) curves were used to evaluate accuracy of therapy response prediction. RESULTS:The change percentages of Attenuation (Δ-Attenuation-A and Δ-Attenuation-V), IC (ΔICA and ΔICV) and NIC (ΔNICA and ΔNICV) pre- and post-therapy correlate with the change percentage of D (ΔD). Among these, ΔICA strongly correlates with Δ D (r = 0.793, P < 0.001). The areas under ROC curves generated using Δ-Attenuation-A, ΔICA, and ΔNICA are 0.796, 0.900, and 0.880 with the corresponding cutoff value of 9.096, −15.692, and −4.7569, respectively, which are significantly different (P < 0.001). CONCLUSIONS:The quantitative parameters of DECT iodine map, especially iodine concentration, in arterial phase provides a new quantitative image marker to predict therapy response of patients diagnosed with advanced NSCLC.

中文翻译:

使用双能计算机断层扫描碘图评估非小细胞肺癌的治疗反应

目的:探讨双能计算机断层扫描(DECT)定量参数评估晚期非小细胞肺癌(NSCLC)治疗反应的可行性,与基于实体瘤疗效评价标准的传统增强CT参数进行比较。 RECIST) 指南。方法:前瞻性纳入 45 例在化疗或同步放化疗 (cCRT) 前后接受 DECT 的不可切除局部晚期 NSCLC 患者。通过比较基线研究与随访,根据 RECIST 指南将患者分为如下两组:疾病控制(DC,包括部分缓解和疾病稳定)和疾病进展(PD)。动脉期和静脉期的直径(D)、衰减、碘浓度和标准化碘浓度(ICA、ICv、NICA、NICv) 以及这些变化在治疗前后的百分比进行了测量和计算。Pearson相关性用于分析各种定量参数之间的相关性。接受者操作特征(ROC)曲线用于评估治疗反应预测的准确性。结果:治疗前后衰减(Δ-衰减-A和Δ-衰减-V)、IC(ΔICA和ΔICV)和NIC(ΔNICA和ΔNICV)的变化百分比与D(ΔD)的变化百分比相关。 . 其中,ΔICA 与ΔD 密切相关(r = 0.793,P < 0.001)。使用 Δ-Attenuation-A、ΔICA 和 ΔNICA 生成的 ROC 曲线下面积分别为 0.796、0.900 和 0.880,对应的截止值分别为 9.096、-15.692 和 -4.7569,差异显着(P < 0.001) . 结论:
更新日期:2021-10-29
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