This month’s Views and Reviews focuses on different aspects of the diagnosis of mosaicism. The first piece was written by Treff and Marin, who discuss the methodologic challenges of preimplantation genetic testing for aneuploidies and how the diagnosis of “mosaic” has led to a significant reduction in the accuracy of such testing. The second article by Viotti et al. provides an excellent overview of outcome data from >1,000 mosaic embryo transfers. The investigators make a strong case for three categorizations of embryos: euploid, aneuploid, and mosaic, and that use of mosaic embryos will prevent the discard of embryos that may lead to live birth. The final piece in this series was written by Besser et al., who discussed the various society recommendations for genetic counseling and prenatal diagnostic testing after mosaic embryo transfer and question whether these are truly data-driven. This collection of pieces will give the reader a deeper understanding of the controversy and management of mosaic embryo transfer.

本月的观点和评论侧重于嵌合体诊断的不同方面。第一篇文章由 Treff 和 Marin 撰写，他们讨论了非整倍体植入前基因检测的方法学挑战，以及“马赛克”的诊断如何导致此类检测准确性的显着降低。Viotti 等人的第二篇文章。提供了超过 1,000 次镶嵌胚胎移植的结果数据的出色概述。研究人员为胚胎的三种分类提供了强有力的理由：整倍体、非整倍体和嵌合体，并且使用嵌合体胚胎将防止丢弃可能导致活产的胚胎。本系列的最后一篇由 Besser 等人撰写，世卫组织讨论了关于镶嵌胚胎移植后遗传咨询和产前诊断测试的各种社会建议，并质疑这些是否真正由数据驱动。这组作品将使读者更深入地了解马赛克胚胎移植的争议和管理。