Intestinal failure-associated liver disease (IFALD) increases mortality of patients with intestinal failure (IF), but lacks effective prevention or treatment approaches. Bile acids, gut microbiota and the host have close and complex interactions, which play a central role in modulating host immune and metabolic homeostasis. Increasing evidence suggests that derangement of the bile acid-gut microbiota (BA-GM) axis contributes to the development of IFALD.

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评论文章：对肠衰竭相关肝病中胆汁酸-肠道菌群轴的见解——重新定义治疗方法

肠衰竭相关肝病 (IFALD) 会增加肠衰竭 (IF) 患者的死亡率，但缺乏有效的预防或治疗方法。胆汁酸、肠道菌群和宿主之间存在密切而复杂的相互作用，在调节宿主免疫和代谢稳态中发挥着核心作用。越来越多的证据表明，胆汁酸-肠道微生物群 (BA-GM) 轴的紊乱有助于 IFALD 的发展。