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Exposure to perfluoroalkyl substances in waste recycling workers: Distributions in paired human serum and urine
Environment International ( IF 11.8 ) Pub Date : 2021-10-28 , DOI: 10.1016/j.envint.2021.106963
Lin Peng 1 , Wang Xu 2 , Qinghuai Zeng 2 , Feiyun Sun 3 , Ying Guo 1 , Shan Zhong 4 , Fei Wang 1 , Da Chen 1
Affiliation  

Occupational exposure to per- and polyfluoroalkyl substances (PFASs) is an emerging public health concern, because of their potential adverse health effects. In this study, concentrations of 21 legacy and alternative PFASs in paired serum and urine samples collected from 163 workers (from five waste recycling plants) were analyzed. The results showed that the average concentration of 21 PFASs in urine samples (66.6 ng mL−1) were higher than in serum (31.3 ng mL−1). Concentrations of perfluorocarboxylates (PFCAs) in urine were also considerably higher than perfluorosulfonates (PFSAs), especially for short-chain PFCAs. Demographic factors (such as sex, age, working age, and job assignment) on PFAS exposure were also assessed based on the obtained results. PFAS concentrations in serum samples from males were significantly higher than in females, and working age was positively (p < 0.05) associated with most PFAS serum levels. Higher levels of PFAS were found in sorters than in workers with other job assignments, such as managers, suggesting that sorters may be directly exposed to PFASs. Interestingly, perfluorophosphonates (PFPAs) were first to be detected in human urine with >80% detection frequency. The average level of three PFPAs in the serum (7.58 ng mL−1) and urine (1.45 ng mL−1) samples appeared to be higher in comparison with most PFCAs and PFSAs. Thus, the toxicity of PFPAs in human beings needs to be further studied.



中文翻译:

废物回收工人暴露于全氟烷基物质:成对的人血清和尿液中的分布

职业暴露于全氟和多氟烷基物质 (PFAS) 是一个新兴的公共卫生问题,因为它们可能对健康产生不利影响。在这项研究中,分析了从 163 名工人(来自五个废物回收厂)收集的配对血清和尿液样本中 21 种遗留和替代 PFAS 的浓度。结果表明,尿液样本中 21 种 PFASs 的平均浓度(66.6 ng mL -1)高于血清(31.3 ng mL -1)。尿液中全氟羧酸盐 (PFCA) 的浓度也显着高于全氟磺酸盐 (PFSA),尤其是对于短链 PFCA。还根据获得的结果评估了 PFAS 暴露的人口因素(如性别、年龄、工作年龄和工作分配)。男性血清样本中的 PFAS 浓度显着高于女性,工作年龄 与大多数 PFAS 血清水平呈正相关(p < 0.05)。在分拣员中发现的 PFAS 水平高于在其他工作分配的工人(例如经理)中发现的,这表明分拣员可能直接接触 PFAS。有趣的是,全氟膦酸盐(PFPA)首先在人尿中被检测到,检测频率>80%。血清中三种 PFPA 的平均水平(7.58 ng mL-1 ) 和尿液 (1.45 ng mL -1 ) 样本与大多数 PFCA 和 PFSA 相比似乎更高。因此,PFPAs对人体的毒性有待进一步研究。

更新日期:2021-10-28
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