当前位置: X-MOL 学术Nat. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy
Nature Medicine ( IF 82.9 ) Pub Date : 2021-10-28 , DOI: 10.1038/s41591-021-01503-6
Jana Blazkova 1 , Feng Gao 2, 3 , Manukumar Honnayakanahalli Marichannegowda 2, 4 , J Shawn Justement 1 , Victoria Shi 1 , Emily J Whitehead 1 , Rachel F Schneck 1 , Erin D Huiting 1 , Kathleen Gittens 5 , Mackenzie Cottrell 6 , Erika Benko 7 , Colin Kovacs 7 , Justin Lack 8, 9 , Michael C Sneller 1 , Susan Moir 1 , Anthony S Fauci 1 , Tae-Wook Chun 1
Affiliation  

Certain infected individuals suppress human immunodeficiency virus (HIV) in the absence of anti-retroviral therapy (ART). Elucidating the underlying mechanism(s) is of high interest. Here we present two contrasting case reports of HIV-infected individuals who controlled plasma viremia for extended periods after undergoing analytical treatment interruption (ATI). In Participant 04, who experienced viral blips and initiated undisclosed self-administration of suboptimal ART detected shortly before day 1,250, phylogenetic analyses of plasma HIV env sequences suggested continuous viral evolution and/or reactivation of pre-existing viral reservoirs over time. Antiviral CD8+ T cell activities were higher in Participant 04 than in Participant 30. In contrast, Participant 30 exhibited potent plasma-IgG-mediated neutralization activity against autologous virus that became ineffective when he experienced sudden plasma viral rebound 1,434 d after ATI due to HIV superinfection. Our data provide insight into distinct mechanisms of post-treatment interruption control and highlight the importance of frequent monitoring of undisclosed use of ART and superinfection during the ATI phase.



中文翻译:

抗逆转录病毒治疗中断后两名 HIV 感染者长期病毒学控制的不同机制

在没有抗逆转录病毒疗法 (ART) 的情况下,某些感染者会抑制人类免疫缺陷病毒 (HIV)。阐明潜在的机制具有很高的兴趣。在这里,我们提出了两个对比鲜明的 HIV 感染者病例报告,这些病例报告在接受分析治疗中断 (ATI) 后长期控制血浆病毒血症。在第 1,250 天前不久检测到的次优 ART 经历了病毒性事件并开始未公开的自我管理的参与者 04 中,血浆 HIV env序列的系统发育分析表明随着时间的推移病毒持续进化和/或预先存在的病毒库重新激活。抗病毒 CD8 +参与者 04 的 T 细胞活性高于参与者 30。相比之下,参与者 30 表现出强大的血浆 IgG 介导的对自体病毒的中和活性,当他在 ATI 后 1,434 天由于 HIV 二次感染而经历突然的血浆病毒反弹时,这种自体病毒变得无效。我们的数据提供了对治疗后中断控制的不同机制的洞察,并强调了在 ATI 阶段频繁监测未公开使用的 ART 和重复感染的重要性。

更新日期:2021-10-28
down
wechat
bug