Sexual- and gender-minority individuals experience minority stress, which is hypothesized to underlie the mental-health disparities affecting these populations. Drawing on advances in the classification of mental disorders, we argue that transdiagnostic approaches hold great promise for understanding and reducing these disparities. In contrast to traditional diagnostic approaches, which have limited construct validity and have produced a piecemeal literature, transdiagnostic approaches (a) are evidence based, (b) account for diffuse patterns of disparities and comorbidity, (c) pinpoint psychological mechanisms linking minority stress to poor mental health, (d) reduce scientific stigma, and (e) identify efficacious and efficient points of intervention for treatment of negative outcomes of minority stress.

性少数群体和性别少数群体会经历少数群体压力，据推测，这是影响这些群体的心理健康差异的基础。借鉴精神障碍分类的进展，我们认为跨诊断方法对理解和减少这些差异具有很大的希望。与构建有效性有限并产生零散文献的传统诊断方法相比，跨诊断方法 (a) 是基于证据的，(b) 解释差异和共病的分散模式，(c) 查明将少数群体压力与心理健康状况不佳，(d) 减少科学污名，以及 (e) 确定有效和高效的干预点，以治疗少数群体压力的负面结果。