Pediatric low-grade gliomas (pLGGs) arise primarily at early stages of development. The molecular mechanisms of pLGG gliomagenesis are unclear, as is the progenitor cell of origin. In this issue of Developmental Cell, Jecrois et al. show that NF1-associated optic pathway gliomas originate from migrating glial progenitors that have distinct MEK/ERK dependency.

中文翻译：

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抑制 ERK/MAPK 信号作为预防 1 型神经纤维瘤病婴儿视神经胶质瘤的潜在疗法

小儿低级别胶质瘤 (pLGG) 主要出现在发育的早期阶段。pLGG 胶质瘤发生的分子机制尚不清楚，起源的祖细胞也是如此。在本期Developmental Cell 中，Jecrois 等人。表明 NF1 相关的视通路神经胶质瘤起源于迁移的具有明显 MEK/ERK 依赖性的神经胶质祖细胞。